胃癌组织中Her-2／neu基因的表达及其临床意义

目的：检测Her-2／neu基因在胃癌组织中的蛋白表达，探讨其表达与胃癌患者临床病理指标及预后之间的关系。方法；收集手术切除胃癌患者临床病理资料，采用免疫组织化学SP法检测石蜡组织切片Her-2／neu基因表达水平，分析与临床病理指标的关系及意义。结果：检测342例手术切除胃癌标本Her-2／neu蛋白表达阳性90例（26．32％）。Her-2／neu基因表达在组织学类型、分化程度、浸润程度的组别间差异均无统计学意义（P〉0．05），而在肿瘤是否伴有淋巴结转移、远处转移和生存时间的组别间差异具有统计学意义（P〈0．05）。结论：Her-2／neu基因表达上调与淋巴结转移、远处转移及不良预后相关，可作为评估胃癌预后的重要参考指标。针对Her-2／neu基因靶点进行胃癌的分子靶向治疗有助于控制病程进展。

Expression and Clinical Significance of Her-2/neu Gene in Gastric Carcinoma

Objective： To study the expression of Her-2/neu gene in gastric cancer tissues. The relationship between Her-2/neu gene expression and the clinicopathological indices,the prognosis of gastric cancer patients was also studied in our research. Methods：342 gastric cancer tissues paraffin were detected with immunohistochemistry SP. To explore the relationship between the expression of Her-2/neu gene and clinical significance. Results：90 tissue samples were positive in Her-2/neu gene expression, and the positive ratio is 26.32%. The expression of Her-2/neu gene in different groups of histological type, histological grade and depth of invasion was no significant difference （P〉0. 05）. However, the expression of Her-2/neu gene in different groups of lymph node metastasis, distant metastasis and the survival time was statistically significant difference （P〈0. 05）. Conclusion： The high expression of Her-2/neu gene is closely related with lymph node metastasis and distant metastasis in the progress of gastric cancer. The expression of Her-2/neu gene could be used as an important indicator to evaluate prognosis of gastric cancer. Her-2/neu gene could be used as a molecular targeting in the treatment of gastric cancer.