|
|||||
|
|
| 四川彝族麻风易感性和HLA—DRB1和HLA—DQB1等位基因的相关性研究 | |
| 引用本文： | 毛翀,宁涌,熊俊浩,雍刚,罗枚. 四川彝族麻风易感性和HLA—DRB1和HLA—DQB1等位基因的相关性研究[J]. 中国麻风杂志, 2011, 0(2): 83-86 |
| 作者姓名： | 毛翀 宁涌 熊俊浩 雍刚 罗枚 |
| 作者单位： | [1]泸州医学院,四川泸州646000 [2]四川省医学科学院·四川省人民医院皮肤病性病研究所,成都610031 [3]中国医学科学院·输血研究所,成都610031 |
| 摘 要： | 目的：分析四川省彝族人群HLA—DRB1、HIA—DQB1等位基因与麻风的相关性。方法：运用聚合酶链反应-序列特异性引物（PCR—ssP）方法，对四川省彝族100例麻风患者和100例健康对照分别进行HLA—DRB1和HLA—DQB1等基位因检测，并比较病例组和对照组之间等位基因频率的差异。结果：麻风病例组HIJA—DRB1＊13等位基因频率较对照组显著增高（P〈0．05）。结论：Hu—DRB1＊13可能与四川省彝族麻风的易感性相关。 |
| 关 键 词： | 麻风 彝族 HLA-DRB1 DQB1 PCR—SSP |
Study on the association between HLA- DRB1 and HLA-DQB1 loci, and leprosy susceptibility in Yi nationality, Sichuan Province, China |
|
| Affiliation: | Mao Chong, Ning Yong, Xiong Junhao, et al. (Luzhou Medical College. Luzhou, 646000) |
| Abstract: | Objective： To analyze the assoeiation of the HLA - DRB1 and HLA- DQB1 loci with leprosy susceptibility in Yi nationality, Sichuan Province, China. Methods： Polymerase chain reaction - sequence specific primers （PCR- SSP） was used to genotype HLA- DRB1 and HLA- DQB1 alleles in 100 patients and 100 healthy controls. Results： The frequency of allele HL4 - DRB1＊- 13 was significantly higher in leprosy patients than lhat in normal controls. Conclusion： HLA - DRB1＊ 13 may be related to leprosy susceptibility in Chinese Yi nationality. |
| Keywords: | leprosy Yi nationality HLA- DRB1/DQB1 PCR - SSP |
| 本文献已被 维普 等数据库收录！ | |