| 刺五加总黄酮对大鼠脑缺血后神经元的保护作用 |
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| 引用本文： | 王志龙,刘志新,周彬,石学魁. 刺五加总黄酮对大鼠脑缺血后神经元的保护作用[J]. 牡丹江医学院学报, 2008, 29(4) |
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| 作者姓名： | 王志龙 刘志新 周彬 石学魁 |
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| 作者单位： | 牡丹江医学院,黑龙江,牡丹江,157011;牡丹江心血管病医院,黑龙江,牡丹江,157000 |
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| 基金项目： | 黑龙江省卫生厅科研项目 |
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| 摘 要： | 目的：探讨剃五加总黄酮对大鼠脑缺血后神经元损伤的影响。方法：采用大脑中动脉栓塞方法制备大鼠脑缺血模型；用神经元尼氏体甲苯胺蓝特殊染色法观察大鼠脑缺血后缺血区神经元损害情况。结果：与假手术组比较，模型组大脑皮层缺血侧神经元缺失以及尼氏体消失明显（P〈0.01）；治疗组虽然也存在神经元缺失及尼氏体消失情况，但完整神经元数明显多于模型组（P〈0.01）。结论：经大脑中动脉栓塞方法建立的大鼠脑缺血模型证实了刺五加总黄酮的脑保护脑作用，抑制缺血性脑损伤，对神经细胞起一定的保护作用。
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| 关 键 词： | 尼氏体 急性脑缺血 刺五加 总黄酮 HE染色 |
STUDY ABOUT THE INFLUENCE OF TOTAL FLAVONOID OF ACANTHOPANAX SENTICOSUS HAMS ON NISSL BODY OF CEREBRAL TISSUE AFTER ACUTE CEREBRAL ISCHEMIA IN RATS |
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| Wang Zhilong et al. STUDY ABOUT THE INFLUENCE OF TOTAL FLAVONOID OF ACANTHOPANAX SENTICOSUS HAMS ON NISSL BODY OF CEREBRAL TISSUE AFTER ACUTE CEREBRAL ISCHEMIA IN RATS[J]. Journal of Mudanjiang Medical College, 2008, 29(4) |
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| Authors: | Wang Zhilong et al |
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| Affiliation: | Wang Zhilong et al(Mudanjiang Medical Collge Heilongliang Mudanjiang 157011) |
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| Abstract: | Objective:To explore the change of macrophage in cerebral tissue after acute cerebral ischemia in rats and the protection of total flavonoid of Acanthopanax senticosus Harms.Methods:The model of focal after cerebral ischemia in rats was made by middle cerebral artery occlusion(MCAO).Results:Compared with sham operation group and pseudopration group,the number of macrophage of model group increases differently(P<0.01).The number of macrophage decreased after using total flavonoid of Acanthopanax senticosus h... |
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| Keywords: | Nissl body Acute cerebral ischemia Acanthopanax senticosus harms Total flavonoid HE staining |
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