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| ABCB1基因多态性和P-糖蛋白表达的相关性 | |
| 引用本文： | 赵富磊,李骞,张峻. ABCB1基因多态性和P-糖蛋白表达的相关性[J]. 国际遗传学杂志, 2017, 40(1). DOI: 10.3760/cma.j.issn.1673-4386.2017.01.006 |
| 作者姓名： | 赵富磊 李骞 张峻 |
| 作者单位： | 昆明医科大学第一附属医院临床药学科,650000 |
| 基金项目： | The National Natural Science Foundation of China，Yunnan Applied Basic Research projects-Joint Special Fund Project (2015FB029)国家自然科学地区基金资助项目，云南省应用基础研究计划-昆医联合专项基金资助项目 |
| 摘 要： | p-糖蛋白作为一种广泛分布于全身各组织和器官的重要转运体,影响多种药物的体内的吸收、分布、代谢和排泄过程,还能防止外源性有害物质的侵入.p-糖蛋白由ABCB1基因编码,ABCB1基因多态性决定p-糖蛋白的蛋白表达量,进而影响p-糖蛋白的体内的功能作用.单核苷酸多态性(SNP)是P-糖蛋白产生变异的重要影响因素,可决定不同个体对药物治疗的不同应答,人体中存在的非同义和同义SNP均可对P-糖蛋白的转运功能产生重要影响.本文将对各组织器官中,ABCB1基因多态性与p-糖蛋白表达量的相关性进行综述. |
| 关 键 词： | p-糖蛋白 ABCB1 基因多态性 表达 单核苷酸多态性 |
Association between ABCB1 gene polymorphism and P-glycoprotein expression |
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| Zhao Fulei,Li Qian,Zhang Jun. Association between ABCB1 gene polymorphism and P-glycoprotein expression[J]. International JOurnal of Genetics, 2017, 40(1). DOI: 10.3760/cma.j.issn.1673-4386.2017.01.006 | |
| Authors: | Zhao Fulei Li Qian Zhang Jun |
| Abstract: | P-glycoprotein (P-gp) is widely not only involved in the drug absorption,distribution,metabolism and excretion,but also prevents the invasion of harmful exogenous substances.P-glycoprotein is encoded by the ABCB1 gene,ABCB1 gene polymorphism determines the protein expression of P-glycoprotein,and affects the function of P-glycoprotein in vivo.Single nucleotide polymorphism (SNP) is an important factors influencing P-glycoprotein mutation,and individual response to drug treatment.The non-synonymous and synonymous SNPs can both influence the transportation function of P-glycoprotein in humans.In this review,the correlation between ABCB1 gene polymorphism and P-glycoprotein expression in various tissues and organwere reviewed. |
| Keywords: | P-glycoprotein ABCB1 Gene polymorphism Expression Single nucleotide polymorphism |
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