2型糖尿病合并颈动脉狭窄患者血清FGF23水平与颈动脉斑块稳定性的关联性研究

目的:探讨血清FGF23对2型糖尿病合并颈动脉狭窄(ICAS)患者不稳定斑块稳定性的作用。方法:选取糖尿病患者78例,分为无ICAS(WICAS)组47例和ICAS组31例,ICAS组行颈动脉内膜切除术。比较2组的血清FGF23、骨保护素(OPG)水平、颈动脉狭窄程度、颈动脉斑块稳定性等。另外,对ICAS组血清FGF23水平与颈动脉狭窄、颈动脉斑块的稳定性及其与炎性细胞因子超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)的相关性进行评估。结果:与WICAS组相比,ICAS组的FGF23水平更高,差异有统计学意义(P0.05),且FGF23水平与ICAS组不稳定斑块的稳定性显著相关(P0.001)。结论:2型糖尿病颈动脉狭窄患者血清FGF23水平与患者颈动脉狭窄斑块不稳定性明显相关。

Relationship between Serum FGF23 Level and Carotid Plaque Stability in Patients with Type 2 Diabetes Mellitus Combined with Carotid Artery Stenosis

Objective:To investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.Methods:Seventy-eight cases of patients with type 2 diabetes mellitus were enrolled,and were divided into without internal carotid artery stenosis (WICAS) group (n=47) and internal carotid artery stenosis (ICAS) group (n=31).The serum level of FGF23 and osteoprotegerin (OPG),the degree of carotid stenosis,carotid plaque stability and cardiovascular disease history were analyzed and compared between the 2 groups.Whether serum level of FGF23 is associated with intemal carotid artery stenosis and carotid plaque stability,and whether it correlates with inlammatory cytokines High-Sensitivity C-reactive protein (Hs-CRP) and interleukin-6 (IL-6) were analyzed.Results:The serum level of FGF23 in ICAS group (67.7±7.8)pg/mL] was significant higher than that in WICAS group (43.8±6.5)pg/mL] (P＜0.05).The serum level of FGF23 was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis (P＜0.001).Conclusion:The serum level of FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.