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| 肥厚型心肌病分子研究进展 | |
| 引用本文： | 黄华洁,熊符,郑华. 肥厚型心肌病分子研究进展[J]. 国际遗传学杂志, 2017, 40(3). DOI: 10.3760/cma.j.issn.1673-4386.2017.03.009 |
| 作者姓名： | 黄华洁 熊符 郑华 |
| 作者单位： | 1. 510515 广州,南方医科大学南方医院心血管内科;510515 广州,南方医科大学医学遗传学教研室;2. 南方医科大学医学遗传学教研室, 广州,510515;3. 南方医科大学南方医院心血管内科, 广州,510515 |
| 基金项目： | Natural Science Foundation of Guangdong，President Foundation of Nanfang Hospital (2013B008)广东省自然科学基金，南方医院院长基金 |
| 摘 要： | 肥厚型心肌病(hypertrophic cardiomyopathy,HCM)是常见遗传性心血管疾病,其发病率可达1/500.该病是目前年轻运动员心源性猝死的重要病因,可在各个年龄段发病,其中50％～70％HCM由基因突变所致.近年来,HCM的分子研究已取得较大进展,本文就HCM相关的主要致病基因及其分子机制作一综述. |
| 关 键 词： | HCM 致病基因 分子机制 |
Research progress on the molecular mechanisms of Hypertrophic Cardiomyopathy |
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| Huang Huajie,Xiong Fu,Zheng Hua. Research progress on the molecular mechanisms of Hypertrophic Cardiomyopathy[J]. International JOurnal of Genetics, 2017, 40(3). DOI: 10.3760/cma.j.issn.1673-4386.2017.03.009 | |
| Authors: | Huang Huajie Xiong Fu Zheng Hua |
| Abstract: | Hypertrophic cardiomyopathy (HCM),affecting 1 in 500 individuals worldwide,is the most common inherited cardiovascular disorder.In addition,it is the most frequent cause of sudden death in young athletes and people can suffer from HCM at all ages.It is supposed that 50％ ～ 70％ HCM result from gene mutation.In recent years,great progress has been made at the field of studying on the molecular mechanisms underlying HCM pathology,which are reviewed. |
| Keywords: | Hypertrophic cardiomyopathy Gene Molecular mechanism |
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