某地区妊娠早期妇女碘营养状况与甲状腺功能减退症的相关性分析

目的研究分析甘肃地区妊娠早期妇女碘营养的实际情况,探究妊娠早期妇女碘营养的情况与其甲状腺功能减退症之间存在的关系。方法选取2015年2月至2016年5月于甘肃省平凉市庄浪县计划生育服务站进行常规产前检查的早期妊娠妇女200例作为研究对象,采用分光光度法测定其在空腹状态下尿碘水平以及血清中的促甲状腺激素、血清游离甲状腺素水平。结果选取的200例中早期妊娠妇女中尿碘水平的范围为8.2~1 857.8mg/L,中位数为178.3mg/L,碘缺乏总例数为79例,所占比例为39.5%,尿碘异常患者总例数为121例,所占比例为60.5%;早期妊娠妇女不同碘水平状态下血清中的促甲状腺激素有明显差异(P0.05),但血清游离甲状腺素水平无显著差异(P0.05);碘摄入异常患者的甲状腺功能减退症发生率为7.1%(9/126),显著高于碘摄入正常者的1.4%(1/74),具有统计学差异(χ~2=3.661,P0.05)。结论甘肃省平凉市庄浪县地区妊娠早期妇女中碘摄取量普遍不足,存在着碘缺乏的现象,碘摄取量不同会明显影响促甲状腺激素水平,且可能是导致甲状腺功能减退症的重要影响因素。

Correlation between iodine status and hypothyroidism among women in early pregnancy

Objective To investigate the iodine status among women in early pregnancy in Gansu Province, and to explore the relationship between iodine nutrition and hypothyroidism.Methods A total of 200 women in early pregnancy undergoing routine prenatal examination during Feb.2015 and May 2016 were selected.The urine iodine, serum thyroid stimulating hormone (TSH) and free thyroxine (FT) levels were measured with spectrophotometry.Results The urine iodine was 8.2~1 857.8 mg/L, median 178.3 mg/L.Iodine deficiency was observed in 79 women (39.5%).Abnormal urine iodine was observed in 121 women (60.5%).There was significant difference in TSH among women with different urine iodine levels (P<0.05), but there was no significant difference in FT (P>0.05).The incidence of hypothyroidism in women with abnormal iodine intake was 7.1% (9/126), which was significantly higher than that in women with normal iodine intake[1.4% (1/74)], with statistical difference (χ2=3.661, P<0.05).Conclusions The iodine intake of women in the early stage of pregnancy in Zhuanglang County is generally insufficient.Iodine deficiency still exists.Different iodine intakes can significantly affect thyroid hormone levels and may be an important cause of hypothyroidism.