| MSI2生物学特性的研究进展 |
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| 引用本文： | 王小刚,刘静,郭庚,李佳润,吴勇强. MSI2生物学特性的研究进展[J]. 国际遗传学杂志, 2017, 40(4). DOI: 10.3760/cma.j.issn.1673-4386.2017.04.008 |
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| 作者姓名： | 王小刚 刘静 郭庚 李佳润 吴勇强 |
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| 作者单位： | 1. 山西医科大学第一医院神经外科, 太原,030001;2. 北京大学第一医院老年病科,100034 |
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| 基金项目： | 国家自然科学基金，中国博士后科学基金，北京博士后工作经费资助项目，山西省自然科学基金，山西省高等学校创新人才支持计划(晋教科[2013]8号)National Natural Science Foundation of China，China Postdoctoral Science Foundation，Project Supported by Beijing Postdoctoral Research Foundation，Shanxi Natural Science Foundation，Program for the Outstanding Innovation Teams of Higher Learning Institutions of Shanxi Province |
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| 摘 要： | MSI2是一种RNA结合蛋白,在人体生理和病理情况下均发挥着重要的作用.MSI2主要表达于神经、造血、胰腺和胃肠组织干细胞内,参与神经系统的发育、细胞增殖分化的调控以及干细胞的生长发育过程,同时,MSI2在实体肿瘤及白血病中异常表达,并参与实体肿瘤及白血病的发生发展.本文通过探讨MSI2的生物学特性及其致病机制,为MSI2作为基因治疗的新靶点提供思路和理论依据.
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| 关 键 词： | MSI2 功能 信号通路 疾病 |
Research progress of the biological characteristics of MSI2 |
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| Wang Xiaogang,Liu Jing,Guo Geng,Li Jiarun,Wu Yongqiang. Research progress of the biological characteristics of MSI2[J]. International JOurnal of Genetics, 2017, 40(4). DOI: 10.3760/cma.j.issn.1673-4386.2017.04.008 |
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| Authors: | Wang Xiaogang Liu Jing Guo Geng Li Jiarun Wu Yongqiang |
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| Abstract: | MSI2 is a RNA-binding protein that plays an important role in physiological and pathological conditions.MSI2 is mainly distributed among neural, hematopoietic, pancreatic and epithelial stem cells.It is important to participate in the development of the nervous system and stem cells and regulate cell proliferation and differentiation.Meanwhile, MSI2 is expressed abnormally in solid tumors as well as leukemia, and participated in the occurrence and development of solid tumors as well as leukemia.This paper focused on the biological characteristics of MSI2 and its role in pathogenic mechanisms, it would provide the theoretical evidence of MSI2 as a new target for gene therapy. |
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| Keywords: | MSI2 Function Signal Pathway Disease |
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