脑死亡动物模型的研究进展

脑死亡动物模型可用于研究器官移植供体的功能,大鼠、猪、狗、家兔、小鼠等是脑死亡动物模型常选用的模式动物.当前具有代表性的脑死亡建模方法,是通过急剧或缓慢颅内加压法建模,制备突发性脑死亡模型和渐进性脑死亡模型.模式动物脑死亡的判定目前尚无统一标准,现有脑死亡动物模型仍存在不足,不能全面模拟临床脑死亡,建模成功的判断与临床上脑死亡的诊断仍有差别.

Research progress of animal model of brain death

Brain death models can be used to study the function of transplant donor. Rats, pigs, dogs, rabbits, mice, etc.are often selected for model animals used in brain death studies. Currently, the typical method to establish a brain death model is to increase intracranial pressure suddenly or gradually by inflation of an epidural balloon catheter. The commonly applied models are sudden onset brain death model and gradual onset brain death model.There are still no uniform criteria for the determination of brain death in the model animal. Additionally, some deficiencies of brain death animal models at present are existed yet, and it cannot fully simulate the clinical brain death. The judgment of a successful brain death model is still different from the diagnosis of clinical brain death.