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| 益气熄风化痰法对慢性癫痫大鼠大脑海马区GAD65表达的影响 | |
| 引用本文： | 项华,沈创鹏,陈晓薇,蔡欣,张横柳.益气熄风化痰法对慢性癫痫大鼠大脑海马区GAD65表达的影响[J].中药新药与临床药理,2011,22(6). |
| 作者姓名： | 项华 沈创鹏 陈晓薇 蔡欣 张横柳 |
| 作者单位： | 1. 阳春市人民医院,广东阳春,529600 2. 广州中医药大学2009级博士生,广州,510405 3. 广州博爱医院,广州,510630 4. 顺德市中医院,广东顺德,528333 5. 广州中医药大学,广州,510405 |
| 基金项目： | 广东省中医药管理局资助课题 |
| 摘 要： | 目的 观察益气熄风化痰法(痫宁片)对氯化锂联合匹罗卡品所致的慢性癫痫大鼠大脑海马区谷氨酸脱羧酶(GAD65)的免疫反应表达的影响,探讨其抗癫痫的可能机制.方法 将70只SD大鼠随机分为空白组、模型组、阳性药对照组和痫宁片组,采用氯化锂和匹罗卡品复制慢性癫痫大鼠模型,分别给予生理盐水、丙戊酸钠、痫宁片灌胃,4周后采用免疫组化SABC法检测大鼠大脑GAD65的表达.结果 阳性药对照组与痫宁片组大鼠大脑GAD65表达较模型组增强(P＜0.05),痫宁片组与阳性药对照组比较,差异无统计学意义(P＞0.05).结论 益气熄风化痰法能增强癫痫大鼠大脑海马区GAD65的表达,这是其抗癫痫的主要机制之一. |
| 关 键 词： | 益气熄风化痰法 痫宁片 癫痫大鼠模型 谷氨酸脱羧酶 |
Influence of Methods of Tonifying Qi, Calming Wind and Eliminating Phlegm on Expression of GAD65 in the Hippocampus of Chronic Epileptic Rats Induced by Lithium-pilocarpine |
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| XIANG Hua,SHEN Chuangpeng,CHEN Xiaowei,CAI Xin,ZHANG Hengliu.Influence of Methods of Tonifying Qi, Calming Wind and Eliminating Phlegm on Expression of GAD65 in the Hippocampus of Chronic Epileptic Rats Induced by Lithium-pilocarpine[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(6). | |
| Authors: | XIANG Hua SHEN Chuangpeng CHEN Xiaowei CAI Xin ZHANG Hengliu |
| Institution: | XIANG Hua1,SHEN Chuangpeng2,CHEN Xiaowei3,CAI Xin4,ZHANG Hengliu5(1.Yangchun People's Hospital,Yangchun 529600 Guangdong,China,2.Ph.D Candidate of Grade 2009 of Guangzhou University of Chinese Medicine,Guangzhou 510405,3.Guangzhou Humanity Hospital,Guangzhou 510630,4.Shunde Hospital of chinese Medicine,Shunde 528333 Guangdong,5.Guangzhou University of Chinese Medicine,China) |
| Abstract: | Objective To observe the influence of the methods of tonifying qi,calming wind and eliminating phlegm(namely Xianning Tablet) on the expression of GAD65 in the hippocampus of epileptic rats induced by lithium-pilocarpine,and to explore its possible antiepileptic mechanism.Methods Seventy SD rats were randomly divided into blank group,model group,positive control group and Xianning Tablet group.The chronic epileptic rat model was induced by lithium-pilocarpine.The rats were given respectively physiological s... |
| Keywords: | Methods of tonifying qi Xianning tablet Chronic epileptic rats model Glutamate decarboxylase |
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