白介素-12在多发伤及合并多器官功能障碍综合征患者外周血中的变化和临床意义

目的　探讨白介素 (IL) 12在多发伤及合并多器官功能障碍综合征 (MODS)患者外周血中创伤后不同时段的动态变化和临床意义。方法　收集 1998年 8月～ 2 0 0 0年 4月多发伤患者 3 6例 ,根据入院时的创伤严重度评分 (ISS)值 ,将患者分为A、B两组 ,ISS <16分为A组 ,15例 ;ISS≥ 16分为B组 ,2 1例 ;选取与多发伤组患者年龄、性别构成相当的健康人 15例为对照组。采用ELISA法对多发伤及合并MODS患者入院后第 1、3、7及 14天不同时段外周静脉血中IL 12水平变化进行检测。结果　A、B两组各时段外周血中IL 12水平较对照组高。合并MODS患者外周血中各时段IL 12水平较未合并MODS者高 (P <0 .0 5 )。结论　IL 12参与机体创伤后引起的免疫反应过程 ,外周血中IL 12的水平变化可作为多发伤严重程度和判定患者是否合并MODS的早期指标之一

Significance of changes of IL-12 level in peripheral blood of patients with multiple trauma coexisting with multiple organ dysfunction syndrome

Objective To appaise the significance of changes in peripheral blood IL-12 level of patients with multiple trauma and multiple organ dysfunction syndrome. Methods IL-12 levels were determined dynamically using the ELISA technique in patients with multiple trauma on day 1, 3, 7, 14 during hospitalization. Results The IL-12 levels in patients with multiple trauma were higher after injury. The IL-12 levels at every time period days in patients complicated with MODS were higher than those in uncomplicated patients. Conclusion The dynamic determination of IL-12 levels is useful in judging the severity of injury, whether or not complicating with MODS in patients with multiple trauma.