| 硝苯地平缓释固体分散体颗粒的制备 |
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| 引用本文： | 沈德凤,张启兴. 硝苯地平缓释固体分散体颗粒的制备[J]. 黑龙江医药科学, 2001, 24(5): 19-19 |
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| 作者姓名： | 沈德凤 张启兴 |
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| 作者单位： | 佳木斯大学化学与药学院;哈高科佳木斯中药有限公司 |
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| 摘 要： | 目的：制备难溶性药物硝苯地平缓释固体分散体以便提高生物利用度。方法：采用固体分散技术（溶剂法）制备固体分散体,并进行体外释放度研究。结果：药物体外释药行为符合Higuchi方程;缓释结果与PVA用量和固体分散体的粒径有主要关系。
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| 关 键 词： | 硝苯地平 缓释颗粒 固体分散体 生物利用度 |
| 修稿时间： | 2001-07-06 |
Preparation of sustained release solid dispersion granules of nifedipin |
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| SHEN Defeng ZHANG Qixing. Preparation of sustained release solid dispersion granules of nifedipin[J]. Heilongjiang Medicine and Pharmacy, 2001, 24(5): 19-19 |
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| Authors: | SHEN Defeng ZHANG Qixing |
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| Affiliation: | SHEN Defeng ZHANG Qixing1 |
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| Abstract: | Objective: Sustained release solid dispersion of nifedipin ,which is sparingly water-soluble,was prepared toincrease the drug bioavailability. Methods: The solid dispersion was prepared by the solvent method and nifedipin release in vitro was investigated. Results: The release profiles of the drug were fitted to Higuchi model. Conclusion: Prolongation of the drug release was primarily associated with amount of PVA and particle size of solid dispersion. |
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| Keywords: | nifedipin sustained release granule solid dispersion bioavailability |
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