A novel ratiometric fluorescent probe for rapid detection of hydrogen peroxide in living cells |
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| Authors: | Linan Hu Jiayi Liu Jie Zhang Hailiang Zhang Pengfei Xu Zhu Chen Enhua Xiao |
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| Affiliation: | Departments of Radiology, The Second Xiangya Hospital, Central South University, Changsha Hunan 410011 P. R. China ; Institute of Clinical Pharmacy & Pharmacology, Jining First People''s Hospital, Jining Medical University, Jining 272000 P. R. China ; Departments of Radiology, Zhuzhou Central Hospital, Zhuzhou Hunan 412000 P. R. China |
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| Abstract: | In this work, we present a new ratiometric fluorescent probe JNY-1 for rapid and convenient detection of H2O2. The probe could selectively and sensitively respond to H2O2 within 10 min. In addition, this probe was successfully applied for monitoring and imaging of H2O2 in liver cancer HepG2 cells under physiological conditions.A new ratiometric fluorescent probe JNY-1 for sensitive detection of H2O2 is presented with selectivity over other reactive oxygen species, reactive nitrogen species, and biologically relevant species. Imaging of H2O2 in liver cancer HepG2 cells was achieved. |
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