68例烧伤患者血清PA和CRP的检测及其临床意义

目的探索烧伤患者血清前白蛋白（PA）与C-反应蛋白（CRP）的变化及其临床意义。方法68例烧伤患者按烧伤总面积大小分为小于15％组38例和大于50％组30例，健康对照组30例。伤后第一天，采用透射免疫比浊法分别测定3组人群血清CRP及PA的浓度。结果烧伤面积大于50％组CRP水平明显高于面积小于15％组，而PA水平烧伤面积大于50％组明显低于面积小于15％组，与CRP水平呈负相关。结论PA水平随着烧伤面积的增加而降低，PA作为烧伤后的炎症程度指标，有十分重要的意义。

Determination of serum prealbumin and C-reactive protein in 68 burn patients and its clinical significance

Objective To investigate the change of serum prealbumin (PA) and C-reactive protein (CRP) in burn patients and its clinical significance.Methods Sixty eight cases of burn patients were divided into two groups,group Ⅰ [n=38,with total burn surface area less than 15% of total body surface area (TBSA)] and groupⅡ(n=30,with total burn surface area more than 50% of TBSA). Thirty healthy people were set as healthy control group. Particle enhanced immunoturbidimetic assay was applied to detecting the serum levels of PA and CRP for all subjects on the day 1 after burns.Results The CRP level was much higher and serum level of PA was much lower in group Ⅱ than that of group Ⅰ,respectively. There existed significant negative correlation between PA and CRP level.Conclusion The level of serum PA decreases significantly along with total burn surface area expansion. PA can be used as a sensitive marker for estimation of inflammation degree after burns.