| 维生素E烟酸酯自乳化制剂处方研究 |
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| 引用本文： | 李丽,王峥,王晶,王中彦,莫凤奎,梁纪军.维生素E烟酸酯自乳化制剂处方研究[J].沈阳药科大学学报,2005,22(4):245-247,251. |
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| 作者姓名： | 李丽 王峥 王晶 王中彦 莫凤奎 梁纪军 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 石药集团,中诺药业有限公司,河北,石家庄,050011 |
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| 摘 要： | 目的研究维生素E烟酸酯(简称VEN)自乳化制剂,探求其最佳处方配比。方法通过溶解度实验、正交筛选和假三角相图的绘制,以形成自乳化区域的大小、溶出度和所得乳滴粒径的大小为指标,对VEN自乳化制剂中的油相、乳化剂及助乳化剂的组成、用量进行筛选,找出最佳的搭配和处方配比。结果在VEN自乳化制剂处方中,以油酸乙酯为油相,聚氧乙烯蓖麻油(EL20)为乳化剂,乙二醇单乙基醚(transcutol)为助乳化剂时,可以获得较好的乳化效果。结论VEN自乳化制剂的最佳处方比例为m(VEN)∶m(油酸乙酯)∶m(EL20)∶m(transcuto1)=1∶0.75∶1.35∶0.9。
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| 关 键 词： | 维生素E烟酸酯 自乳化 剂型改进 |
| 文章编号： | 1006-2858(2005)04-0245-03 |
Self-emulsifying preparation of vitamin E nicotinate |
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| LI Li,WANG Zheng,WANG Jing,WANG Zhong-yan,MO Feng-kui,LIANG Ji-jun.Self-emulsifying preparation of vitamin E nicotinate[J].Journal of Shenyang Pharmaceutical University,2005,22(4):245-247,251. |
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| Authors: | LI Li WANG Zheng WANG Jing WANG Zhong-yan MO Feng-kui LIANG Ji-jun |
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| Institution: | LI Li~1,WANG Zheng~1,WANG Jing~1,WANG Zhong-yan~1,MO Feng-kui~1,LIANG Ji-jun~2 |
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| Abstract: | Objective To search for the optimum formula for the self-emulsification of vitamin E nicotinate.Method Through solubility experiment,orthogonal screening and drawing phase diagram,taking the area of effective self-emulsifying in phase diagram,dissolution and emulsion particle size as parameters,oil,non-ionic surfactant and co-surfactant were screened for the best formula.Results In the formula of vitamin E nicotinate SEDDS,taking ethyl oleate as the oil,EL-20 as the surfactant and transcutol as co-surfactant can get the best effect of emulsifying.Conclusion The optimum formula for self-emulsification of vitamin E nicotinate is m(vitamin E nicotinate) ∶m(ethyl oleate)∶m (EL-20)∶m(transcutol)=1∶0.75∶1.35∶0.9. |
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| Keywords: | vitamin E nicotinate self-emulsifying improving dosage form |
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