血浆胰蛋白酶原激活肽浓度与高脂血症性胰腺炎严重程度的相关性研究

目的研究血浆胰蛋白酶原激活肽（TAP）浓度与高脂血症性胰腺炎（HLP）严重程度的相关性。方法选取确诊的HLP患者43例并按病情程度分为重症组和轻症组，以23例健康体检者为对照组，留取初入院时及入院24h、48h和72h时的血样，测定血浆中TAP浓度和淀粉酶活性。结果HLP重症组患者血浆TAP浓度的平均值显著高于轻症组和对照组。而重症组与轻症组的血浆淀粉酶活性无显著性差异。结论血浆TAP浓度可作为HLP早期诊断和预测严重程度的辅助指标。

Correlation between the plasma concentration of trypsinogen activation peptide and the severity of hyperlipidemic pancreatitis

Objective To investigate the correlation between the concentration of trypsinogen activation peptide （TAP） in plasma and severity of hyperlipidemic pancreatitis（HLP）. Methods A total of 43 patients with the diagnosis of HLP were grouped as mild acute pancreatitis （MAP） and severe acute pancreatitis （SAP） according to the clinical manifestations, and with 23 healthy subjects as control group. The blood samples were collected at 0,24,48 and 72 h respectively after being hospitalized,and TAP levels and amylase activities in plasma from the samples were determined. Results The plasma TAP level in patients with SAP was significantly higher than that in MAP group and control group. In contrast,there was no remarkable difference in the activity of amylase between the MAP and SAP group. Conclusions TAP may be a new marker for early diagnosis and the prediction of severity in HLP.