川芎嗪注射液对大鼠腹膜透析效能的影响

目的 通过动物实验观察川芎嗪对腹膜透析效能的影响，并初步探讨其作用机理。方法 采用空白及实验对照设计，将３６只雄性ＳＤ大鼠平均分为单纯腹透组、多巴胺对照组、川芎嗪常规浓度组及川芎嗪高浓度组４组，观察不同剂量川芎嗪加入腹透液对大鼠尿素氮清除率（ＣＢＵＮ）、肌酐清除率（ＣＣｒ）、尿素氮Ｄ／Ｐ值、肌酐Ｄ／Ｐ值、排液量均显著高于单纯腹透组（ｐ值均小于０．０５），３组间两两比较差异无显著性（ｐ值均大于０．０

Influence of ligustrazine injection on efficiency of peritoneal dialysis in rats

Objective To study the influence of ligustrazine on efficiency of peritoneal dialysis in rats.Methods 36 male SD rats were divided into four groups: the simple-dialysis group, the dopamine group, the conventional doge-ligustrazine groups, and the high doge-ligustrazine groups. The influence of ligustrazine on BUN clearance rate (CBUN), Cr clearance rate (CCr), BUN D/P, Cr D/P , drainage volume and protein concentration of dialysate were observed. Results The CBUN, CCr and drainage volume of the conventional doge-ligustrazine group, the high doge-ligustrazine group and dopamine group, were all higher than the simple-dialysis group (all P <0 05). Every comparison between any two of the three groups were not statistically significant (all P >0 05). The protein concentration of dialysate in the conventional doge-ligustrazine group and the high doge-ligustrazine group were similar to that in the simple-dialysis group (all P >0 05), but the protein concentration of dialysate in the dopamine group was higher than that of the simple-dialysis group, the conventional doge-ligustrazine group and the high doge-ligustrzine group (all P <0 01). Conclusion Ligustrazine injection can enhance the efficiency of peritioneal dialysis and increase the clearance of small molecule solutes in rat, without affecting the protein concentration of dialysate. 40 mg/L or 80 mg/L ligustrazine-containted peritioneal dialysate have similar effects on peritoneal dialysis efficacy, which may be related to increased ultrafiltration and peritoneal blood flow by ligustrazine.