The role of descending inhibition in morphine-induced analgesia |
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| Authors: | C Advokat |
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| Affiliation: | 2. University of Rome Tor Vergata, Rome, Italy;1. Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany;2. Division of Cellular and Molecular Pathology, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany;3. Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68135 Mannheim, Germany;4. Department of Internal Medicine, University of Tübingen, 72074 Tübingen, Germany;5. German Center for Diabetes Research, 85764 Neuherberg, Germany;6. Department of Nephrology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany;7. Institute for Diabetes and Cancer IDC, Helmholtz Center Munich and Joint Heidelberg-IDC Translational, Diabetes Program, University of Heidelberg, INF 410, 69120 Heidelberg, Germany |
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| Abstract: | ![]()
It is generally accepted that morphine produces analgesia through both a direct action in the brain and the spinal cord, and an indirect action by increasing descending inhibitory control of spinal nociceptive input. In examining the evidence for this position, Claire Advokat questions the conclusion that morphine enhances descending, supraspinally mediated inhibition. She presents recent results that support the conclusion that morphine acts in the brain to decrease descending inhibition of spinal nociceptive input. |
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