雷米普利治疗高血压病对NO、vWF的影响

目的:评价雷米普利治疗轻、中度高血压病对一氧化氮(NO)、内皮血管性血友病因子(vWF)的影响。方法:选取轻、中度高血压病患者36例及正常对照组32例,高血压病组服用雷米普利5mg/d,治疗前、治疗3个月后及正常对照组行血浆NO、vWF检测。结果:治疗前血浆NO较正常对照组降低(P<0.05),治疗后血浆NO较治疗前明显升高(P<0.01)。治疗前血浆vWF较正常对照组明显升高(P<0.01),治疗后血浆vWF较治疗前降低(P<0.05)。结论:雷米普利明显升高血浆NO、降低vWF,说明它在降压的同时具有保护血管内皮细胞的功能。

The influence of ramipril on plasma nitric oxide and von-Willebrand factor in the treatment of essential hypertension

Objective: To evaluate the effects of Ramipril on plasma nitric oxide and von-Willebrand factor(vWF) in treating the patients with grade 1 or grade 2 the essential hypertension. Methods:36 cases of patients with grade 1 or grade 2 the essentia hypertension and 32 normal persons were selected. The hypertention group was treated with Ramipril 5 mg/d. Both Plasma NO and vWF were tested before and after 3 months treatment. Results: The plasma NO before treatment in the essentia hypertension group decreased significantly than normal group (P<0.05) and plasma NO after treatment raised significantly than that before treatment (P<0.01). The plasma vWF before treatment in the essentia hypertension group raised significantly than normal group (P<0.01)and plasma vWF after treatment decreased than that before treatment(P<0.05). Conclusion: Ramipril raises plasma NO and decreases plasma vWF significantly. It is shown that Ramipril not only reduces hypertension but also protects function of vascular endothelial cells.