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| 人类疾病基因定位常用的统计学分析方法 | |
| 引用本文： | Sun HX,Fang FD. 人类疾病基因定位常用的统计学分析方法[J]. 中国医学科学院学报, 2001, 23(1): 86-88 |
| 作者姓名： | Sun HX Fang FD |
| 作者单位： | 中国医学科学院中国协和医科大学基础医学研究所 |
| 摘 要： | 人类疾病,特别是多基因遗传病相关基因的定位,是目前医学遗传学和基因研究中的难点和热点。本文简要介绍疾病基因定位的几种常用分析方法,包括连锁分析法(参数法和非参数法)、关联分析和传递不平衡分析的基本原理和应用范围。 |
| 关 键 词： | 人类疾病 基因定位 分析方法 |
| 修稿时间： | 2000-10-10 |
Statistical approaches to gene mapping of human diseases |
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| Sun H X,Fang F D. Statistical approaches to gene mapping of human diseases[J]. Acta Academiae Medicinae Sinicae, 2001, 23(1): 86-88 | |
| Authors: | Sun H X Fang F D |
| Affiliation: | National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China. |
| Abstract: | Gene Mapping of human diseases, especially the complex genetic diseases, has been the difficulty and hotspot in medical genetics and gene study. In this article, the principle and application of several gene mapping methods are discussed, including linkage analysis (parametric and nonparametric linkage analysis), association study and linkage disequilibrium analysis. |
| Keywords: | human diseases gene mapping analysis methods |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |