Synthesis and anti-inflammatory evaluation of some pyrazolo[3,4-b]pyridines |
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| Authors: | Pawan K. Sharma Karan Singh Surender Kumar Pawan Kumar S. N. Dhawan Sukhbir Lal Holger Ulbrich Gerd Dannhardt |
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| Affiliation: | (1) Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, India;(2) Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, 136119, India;(3) Institute of Pharmacy, Johannes Gutenberg-University of Mainz, Staudingerweg 5, 55099 Mainz, Germany;(4) Present address: GVK Biosciences Private Limited, Hyderabad, 500016, India |
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| Abstract: | Novel series of pyrazolo[3,4-b]pyridines with basic skeleton different from the known COX inhibitors were synthesized from 5-amino-1-[4-(aminosulfonyl)phenyl]-3-phenyl-1H-pyrazole, which in turn was prepared by the condensation of (4-sulfamoylphenyl)hydrazine with α-cyanoacetophenone. All the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by carrageenan-induced rat paw edema assay. Some of the most potent compounds were evaluated in different COX and LOX assays. Some of the new compounds were found to possess moderate anti-inflammatory activity. |
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