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| Trophinin在人卵母细胞及着床前胚胎细胞上的表达与意义 | |
| 引用本文： | 王华云,邢福祺,陈士岭,罗琛. Trophinin在人卵母细胞及着床前胚胎细胞上的表达与意义[J]. 南方医科大学学报, 2008, 28(1): 122-124 |
| 作者姓名： | 王华云 邢福祺 陈士岭 罗琛 |
| 作者单位： | 南方医科大学南方医院妇产科,广东,广州,510515 |
| 基金项目： | 致谢：衷心感谢Michiko N.Fukuda教授在实验过程中所给予的帮助与指导! |
| 摘 要： | 目的 研究trophinin在人卵母细胞、着床前胚胎细胞上的表达与意义.方法 采用间接免疫荧光技术、应用激光扫描共聚焦显微镜对9个卵母细胞、16个分裂胚胎及12个囊胚进行了荧光检测.结果 trophinin蛋白在人卵母细胞、分裂胚胎以及囊胚上均有表达,且表达逐渐显著增强(P＜0.05).结论 人囊胚可能通过trophinin与表达有相同粘附分子的着床窗期子宫内膜发生同种粘附,从而在人胚胎着床过程中起重要作用. |
| 关 键 词： | trophinin 卵母细胞,胚胎,人 Trophinin 卵母细胞 着床前 胚胎细胞 表达 意义 embryos preimplantation oocytes human 作用 着床过程 人胚胎 粘附分子 发生 着床窗期子宫内膜 增强 蛋白 结果 荧光检测 |
| 文章编号： | 1673-4254（2008）01-0122-03 |
| 收稿时间： | 2007-03-15 |
| 修稿时间： | 2007-03-15 |
Expression of trophinin in human oocytes and preimplantation embryos |
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| WANG Hua-yun,XING Fu-qi,CHEN Shi-ling,LUO Chen. Expression of trophinin in human oocytes and preimplantation embryos[J]. Journal of Southern Medical University, 2008, 28(1): 122-124 | |
| Authors: | WANG Hua-yun XING Fu-qi CHEN Shi-ling LUO Chen |
| Affiliation: | Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. |
| Abstract: | OBJECTIVE: To investigate the significance of trophinin expression in human oocytes and preimplantation embryos. METHODS: The expression of trophinin in 9 human oocytes, 16 blastomeres and 12 blastocysts were detected by indirect immunofluorescence assay and observed under laser scanning confocal microscope. RESULTS: Human oocytes, blastomeres and blastocysts were all positive for trophinin expression, and the positivity intensified significantly in the course of the embryonic development (P<0.05). CONCLUSION: Trophinin may play an important role in human embryo implantation by mediating homophilic adhesion between the embryo and the endometrium during the implantation window. |
| Keywords: | trophinin oocyte,embryo, human |
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