特发性血小板减少性紫癜的细胞免疫异常研究新进展

长期以来认为特发性血小板减少性紫癜的病因主要是抗体介导的血小板破坏增多，但是体液免疫异常机制并不能解释发病中的所有现象。越来越多的研究表明细胞免疫异常参与了血小板破坏机制。本综述就T细胞耐受、T细胞凋亡异常、T细胞的异常激活、T细胞亚群及其功能改变、T细胞的细胞毒作用等作了概述。

Advances of Research on Abnormality of Cell Immunity in Idiopathic Thrombocytopenic Purpura

It was long believed that platelets are prematurely destroyed in the reticuloendothehal system by platelet autoantibodies in idiopathic thrombocytopenic purpura. However , humoral mechanisms cannot account for all observations made in this disorder, and it is increasingly evident that cellular mechanisms contribute to platelet destruction. In this review the toleramce of T cell, abnormality of T cell apoptosis, abnormal activation of T cells, T cell subtype and its function changes, and T cell-mediated cytotoxicity were summarized.