The protective effect of vitamin E on gastric mucosal injury in ratswith cirrhosis of the liver |
| |
Authors: | Cantürk N Z Cantürk Z Utkan N Z Yenisey C Ozbilim G Gelen T Yalman Y |
| |
Institution: | Kocaeli University, Medical School, Department of General Surgery, Kocaeli, TURKEY;Cumhuriyet University, Medical School, Department of Internal Medicine, Sivas, TURKEY;Kocaeli University, Medical School, Department of General Surgery, Kocaeli, TURKEY;Aydin Menderes University, Medical School, Department of Biochemistry, Aydn, TURKEY;Akdeniz University, Medical School, Department of Pathology, Antalya, TURKEY;Akdeniz University, Medical School, Department of Pathology, Antalya, TURKEY;Cumhuriyet University, Veterinary, Sivas, TURKEY |
| |
Abstract: | OBJECTIVE: To evaluate the functional and morphologic features of stomach in liver cirrhosis model and the cytoprotective effects of Vitamin E. METHODS: Experimental cirrhosis was induced in rats by subcutaneous administration of 0.4 ml CCl4 (diluted 1:4 with olive oil) per kilogram of body weight twice a week for 12 weeks. Rats were divided into three groups. Group 1 was control. Group 2 consisted cirrhotic rats induced by CCl4 and Group 3 cirrhotic rats treated with Vitamin E (intramuscularly 100 mg/kg per day during study). At the end of 12 weeks, gastric mucosal injury was produced by instillation of absolute alcohol via an orogastric tube. After 3 hours, each animal was sacrificed. The stomachs were macroscopically, microscopically and biochemically analyzed. RESULTS: Macroscopic and microscopic area of gastric mucosal injury were significantly larger in cirrhotic rats (P < 0.05). Gastric mucosal injury was more serious in cirrhotic rats as compared with Group 1. With vitamin E treatment, tissue Malondialdehyde (MDA) and glutathione GSH (X)] levels were significantly lower in group 3 as compared with group 2 (P < 0.001). CONCLUSION: Gastric mucosa in cirrhotic rats has distinctive histological and functional abnormalities. These abnormalities can be reversed by Vitamin E or other antioxidants. |
| |
Keywords: | |
本文献已被 万方数据 PubMed 等数据库收录! |
| 点击此处可从《中华医学杂志(英文版)》浏览原始摘要信息 |
| 点击此处可从《中华医学杂志(英文版)》下载免费的PDF全文 |
|