| 陷窝蛋白-1与脑血管病 |
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| 引用本文： | 李红红,彭英.陷窝蛋白-1与脑血管病[J].国外医学：脑血管疾病分册,2014(1):75-78. |
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| 作者姓名： | 李红红 彭英 |
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| 作者单位： | 中山大学孙逸仙纪念医院神经内科,广州510120 |
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| 摘 要： | 陷窝是细胞膜表面富含胆固醇的内陷微区，参与多种生理学过程。陷窝蛋白-1是参与构成陷窝的重要膜蛋白，通过与多种信号蛋白结合而发挥生物学效应。在脑血管病的病理生理学过程中，陷窝蛋白-1参与维持血脑屏障的完整性和动脉粥样硬化斑块的稳定性，而且具有调控炎性介质释放和神经保护作用。文章对陷窝蛋白-1与脑血管病关联性的研究进展进行了综述，旨在为临床治疗提供新的思路。
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| 关 键 词： | 陷窝蛋白1 脑梗死 脑缺血 脑出血 血脑屏障 |
Caveolin-1 and cerebrovascular disease |
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| LI Honghong,PENG Ying.Caveolin-1 and cerebrovascular disease[J].Foreign Medical Sciences Cerebrovascular Diseases,2014(1):75-78. |
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| Authors: | LI Honghong PENG Ying |
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| Institution: | ( Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China) |
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| Abstract: | Caveolae are cholesterol-rich pits on the surface of cell membrane, and participate in various physiological processes. Caveolin-1 is an important membrane protein constituting caveolae. It exerts biological effects through binding a variety of signaling proteins. In the pathophysiological processes of cerebrovascular disease, caveolin-1 participates in maintaining the integrity of blood-brain barrier and stability of atherosclerotic plaques, and has regulating the release of inflammatory mediators and neuroprotection. This article reviews the associated advances in research on the correlation between caveolin-1 and cerebrovascular disease in order to provide a new idea for clinical therapy. |
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| Keywords: | Caveolin 1 Brain Infarction Brain Ischemia Cerebral Hemorrhage Blood-Brain Barrier |
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