慢性阻塞性肺疾病患者C反应蛋白与纤维蛋白原含量的变化分析

目的探讨慢性阻塞性肺疾病(COPD)急性加重期患者血清C反应蛋白(CRP)与血浆纤维蛋白原(Fib)含量的变化及其临床意义。方法分别检测30例COPD患者急性加重期、缓解期及30例健康体检者(对照组)血清CRP、血浆Fib的含量,同时进行动脉血气测定。结果 COPD患者急性加重期CRP、Fib含量较缓解期及对照组均明显升高,缓解期含量较对照组明显升高,差异有统计学意义(P<0.05或P<0.01);动脉血氧分压(PaO2)与血清CRP、血浆Fib含量均呈负相关(P<0.01),动脉血二氧化碳分压(PaCO2)与血清CRP、血浆Fib含量均呈正相关(P<0.01)。结论监测CRP、Fib的含量对于COPD患者的病情、疗效判断、预测预后有一定的临床价值。

Study on significance in changes of serum C-reactive protein and plasma fibrinogen in patients with chronic obstructive pulmonary disease

Objective To study changes in serum level of C-reactive protein（CRP） and plasma level of fibrinogen（Fib） in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods The serum level of CRP and plasma level of Fib were detected in 30 patients with COPD during acute exacerbation and remission stage,and 30 healthy persons for controls.Arterial blood gas analysis was measured at the same time.Results CRP and Fib levels were higher in patients with COPD in acute exacerbation stage than those in remission stage and controls.CRP and Fib levels were negatively correlated with PaO2,and positively correlated with PaCO2.Conclusion The determination of serum level of CRP and plasma level of Fib is of definite significance in assessment of status,therapeutic efficacy and prognosis of patients with COPD.