超敏C-反应蛋白在2型糖尿病并发动脉粥样硬化中的研究

目的 探讨血清超敏C-反应蛋白(Hs-CRP)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)与2型糖尿病并发动脉粥样硬化的关系.方法 150例糖尿病患者(实验组)及50例健康对照者(对照组)均采用免疫比浊法测定Hs-CRP,氧化酶法测定TG、TC、一步法测定LDL-C水平,并进行相关性分析.结果 实验组Hs-CRP、TG、TC、LDL-C较对照组明显升高(P<0.001),血糖控制不良组(C组)中Hs-CRP明显高于血糖控制良好组(A组)和血糖控制一般组(B组)(P<0.01),B组高于A组(P<0.01)且与TG、TC、LDL-C正相关.结论 Hs-CRP、TG、TC、LDL-C与2型糖尿病并发动脉粥样硬化密切相关,可作为风险预测指标预测2型糖尿病并发症出现.

Research on high-sensitivity C-reactive protein in type 2 diabetes patients with atherosclerosis

Objective To probe into the relationship between high-sensitivity C-reactive protein(Hs-CRP),cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C) and the emergence of atherosclerosis in patients with type 2 diabetes.Methods Hs-CRP,LDL-C,and TG and TC were detected by immunoturbidimetry,one-step method and oxidase method respectively in 150 diabetes patients(experimental group) and 50 healthy controls(control group).Results The levels of Hs-CRP,TG,TC and LDL-C were significantly higher in experimental group than in the control group(P<0.001).The level of Hs-CRP in group C(Poor blood sugar control) was obviously higher than group B(Blood sugar control general) and group A(Good blood glucose control)(P<0.01) and higher in group B than group A(P<0.01) Hs-CRP level was positively correlated with the levels of TG,TC and LDL-C.Conclusion The levels of Hs-CRP,TG,TC and LDL-C are closely related with atherosclerosis in patients with type 2 diabetes,they can be used as risk predictors for type 2 diabetes-related atherosclerosis.