| DETECTION OF TELOMERASE ACTIVITY IN BREAST CARCINOMA |
| |
| 引用本文： | 杨文涛,许良中,张泰明,朱伟萍,李小妹,金爱萍. DETECTION OF TELOMERASE ACTIVITY IN BREAST CARCINOMA[J]. 中国癌症研究, 1998, 10(4): 292-296. DOI: 10.1007/BF02962181 |
| |
| 作者姓名： | 杨文涛 许良中 张泰明 朱伟萍 李小妹 金爱萍 |
| |
| 作者单位： | Yang Wentao Xu Liangzhong Zhang Taiming Zhu weiping Li Xiaomei Jin Aiping Laboratory of Molecular pathology，Shanghai Medical University，Cancer Hospital，Shanghai，200032 |
| |
| 摘 要： | Ｔｅｌｏｍｅｒｅｓａｒｅｓｐｅｃｉａｌｉｚｅｄｓｔｒｕｃｔｕｒｅｓａｔｔｈｅｅｎｄｓｏｆｅｕｋａｒｙｏｔｉｃｃｈｒｏｍｏｓｏｍｅｓｗｈｉｃｈｆｕｎｃｔｉｏｎｉｎｍａｉｎｔａｉｎｉｎｇｃｈｒｏｍｏｓｏｍａｌｉｎｔｅｇｒｉｔｙ１Ｈｕｍａｎｔｅｌｏｍｅｒ...
|
Detection of telomerase activity in breast carcinoma |
| |
| Wentao Yang,Liangzhong Xu,Taiming Zhang,weiping Zhu,Xiaomei Li,Aiping Jin. Detection of telomerase activity in breast carcinoma[J]. Chinese Journal of Cancer Research, 1998, 10(4): 292-296. DOI: 10.1007/BF02962181 |
| |
| Authors: | Wentao Yang Liangzhong Xu Taiming Zhang weiping Zhu Xiaomei Li Aiping Jin |
| |
| Affiliation: | (1) Laboratory of Molecular pathology, Shanghai Medical University, Cancer Hospital, 200032 Shanghai |
| |
| Abstract: | Objective: To investigate the significance of telomerase activity in breast carcinoma with its respect to axillary lymph node status Methods: Telomerase activity was analyzed in 88 breast carcinomas and 16 benign breast lesions, using polymerase chain reaction (PCR) based telomeric repeat amplification protocol (TRAP) assay Results: Telomerase activity was detected in 75 (85%) of 88 breast carcinomas (including three breast carcinomas in situ which were all positive for telomerase activity), whereas in benign breast lesions analyzed only 2(12 5%) of 16 cases were positive for telomerase activity The difference between the two groups was statistically significant ( P <0 001) Besides, telomerase activity was expressed significantly higher in node positive breast carcinoma (93%) than in node negative ones (77%) ( P <0 05) Conclusion: Our results suggest that telomerase activation plays an important role during breast carcinoma development It is possible that this enzyme may serve as an early indication of breast carcinoma |
| |
| Keywords: | Telomerase activity Breast carcinoma Telomeric repeat amplification protocol (TRAP) |
| 本文献已被 CNKI 万方数据 SpringerLink 等数据库收录！ |
