| HIV/AIDS病人HAART相关的高乳酸血症/乳酸酸中毒研究进展 |
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| 引用本文： | 梁洪远,肖江,赵红心.HIV/AIDS病人HAART相关的高乳酸血症/乳酸酸中毒研究进展[J].中国艾滋病性病,2011(3):363-366. |
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| 作者姓名： | 梁洪远 肖江 赵红心 |
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| 作者单位： | 首都医科大学附属北京地坛医院感染一科; |
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| 基金项目： | 十一五重大专项“北京市朝阳区艾滋病和病毒性肝炎等重大传染病综合防治示范区建设研究(2009ZX10004-903)~~ |
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| 摘 要： | 在发展中国家,由于高效抗反转录病毒治疗(HAART)的引进和广泛地应用,使得艾滋病(HIV/AIDS)病人的患病率和病死率大大下降。中国自从2003年开始,在政府的倡导下,广泛开展艾滋病的免费抗病毒治疗,其主要的方案是以核苷类药物(NRTIs)司他夫定(d4T)、齐多夫定(AZT)或去羟肌苷(DDI)为骨干的,而核苷类药物的主要不良反应是线粒体毒性。在线粒体毒性中最严重的甚至是威胁生命的高乳酸血症和乳酸酸中毒。文章就高乳酸血症的发生率、发生机制、临床表现、诊断、治疗和预后进行综述。
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| 关 键 词： | 高效抗反转录病毒治疗 核苷类药物 高乳酸血症 乳酸酸中毒 |
The research progress in HAART-related hyperlactacidemia/lactic acidosis in HIV/AIDS patients |
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| LIANG Hong-yuan,XIAO Jiang,ZHAO Hong-xin..The research progress in HAART-related hyperlactacidemia/lactic acidosis in HIV/AIDS patients[J].Chinese JOurnal of Aids & STD,2011(3):363-366. |
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| Authors: | LIANG Hong-yuan XIAO Jiang ZHAO Hong-xin |
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| Institution: | LIANG Hong-yuan,XIAO Jiang,ZHAO Hong-xin.(Division 1 of Department of Infectious Diseases.Ditan Hospital,Beijing.100015 China) |
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| Abstract: | Since HAART are taken in AIDS patients in developing countries,the morbidity and mortality of opportunistic infections have been significantly reduced.Since 2003,free HAART treatment have been carried out with support of the Chinese government,in which nucleoside analogs such as stavudine,zidovudine or didanosine are treated as backbone.The main side effect of nucleoside analogs is mitochondrial toxicity,resulting in hyperlactacidemia/lactic acidosis.In this review,we have summarized the incidence,mechanism... |
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| Keywords: | HAART Nucleoside analog Hyperlactacidemia Lactic acidosis |
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