酮洛芬的脊髓镇痛作用及其机制

目的研究酮洛芬的脊髓镇痛作用及作用机制。方法采用温浴法、热板法观察动物痛阈变化。结果鞘内注射（ｉｔｈ）酮洛芬１．６～３．２ｍｇ·ｋｇ－１具有明显镇痛作用，全身用药需１６ｍｇ·ｋｇ－１才具有同等镇痛效应。ｉｔｈ与ｉｐ药物有效剂量比为１∶１０。ｉｔｈ用药，作用可被ｉｐ利血平、ｓｃ哌唑嗪、育亨宾阻滞。结论酮洛芬具有脊髓镇痛作用，其机制与ＮＥ－α受体系统介导的内源性镇痛系统密切相关

Spinal analgesic effect and mechanism of ketoprofen, a NSAID

AIM Spinal analgesia and mechanism of ketoprofen in mice were studied. METHODS The tail immersion test and hot plate test were used to observe variations of pain threshold of mice. RESULTS Dose dependent analgesia was observed following intrathecal administration of KPF 16 or 32 mg·kg-1,the ratio of effective doses for intrathecal/systemic (ip ) KPF was 1∶10, The analgesia of intrathecal KPF 16 mg·kg-1 was abolished when the animals were pretreated with reserpine (3 mg·kg-1,ip); α1 receptor antagonist prazosin (10 mg·kg-1, sc) or α2 receptor antagonist yohinbine (4 mg·kg-1, sc). CONCLUSIONS KPF has noradrenergic nerve mediated spinal analgesia.