Drug induced hypothermia in adult and senescent rats |
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| Authors: | J R Martin A Fuchs J Harting |
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| Affiliation: | Experimentell-medizinische Forschung, Abteilung Pharmakologie, E. Merck Frankfurter Strasse 250, D-6100 Darmstadt, Federal Republic of Germany |
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| Abstract: | ![]()
Temperature regulation was evaluated in senescent (34-40 month old) and adult (8-9 month old) female Iva:WIWU and Emd:Wi-AF/Han rats. Injection of 1.5 mg/kg BW apomorphine HCl or 1.0 mg/kg BW oxotremorine sesquifumarate produced comparable maximal hypothermic responses in adult and senescent rats. However, the latency to reach maximal hypothermia after oxotremorine (but not apomorphine) was longer in senescent than in adult rats of both strains. |
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| Keywords: | Thermoregulation Senescence Age difference Apomorphine Oxotremorine Strain difference Aging Drug induced hypothermia |
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