| 清脑镇痛液对偏头痛动物模型血清中一氧化氮、一氧化氮合酶含量的影响 |
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| 引用本文： | 方选,李昇刚,孙振平,扆雪涛,杨娟. 清脑镇痛液对偏头痛动物模型血清中一氧化氮、一氧化氮合酶含量的影响[J]. 中国药事, 2011, 0(9): 896-898 |
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| 作者姓名： | 方选 李昇刚 孙振平 扆雪涛 杨娟 |
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| 作者单位： | (山东省青岛市药品检验所,青岛266071) |
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| 摘 要： | 目的研究清脑镇痛液对偏头痛模型NO、NOS含量的影响。方法 wistar大鼠随机分为6组:高、中、低剂量组、阳性对照组、偏头痛模型组、空白对照组。皮下注射NTG复制偏头痛模型,造模4h后测定各组NO、NOS的含量。结果模型组NO、NOS含量与空白对照组比较均有显著性升高(P<0.01)。高剂量组及阳性对照组NO、NOS含量与模型组比较均有显著性降低(P<0.01)。结论清脑镇痛液可抑制由NTG诱导的NO和NOS异常升高水平,从而发挥治疗偏头痛的作用。
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| 关 键 词： | 清脑镇痛液 偏头痛 一氧化氮 一氧化氮合酶 |
Effect of Qingnaozhentong Liquor on NO and NOS Contents in Serum of Migraine Animal Models |
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| Fang Xuan,Li Shenggang,Sun Zhenping,Yi Xuetao,Yang Juan. Effect of Qingnaozhentong Liquor on NO and NOS Contents in Serum of Migraine Animal Models[J]. Chinese Pharmaceutical Affairs, 2011, 0(9): 896-898 |
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| Authors: | Fang Xuan Li Shenggang Sun Zhenping Yi Xuetao Yang Juan |
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| Affiliation: | Fang Xuan,Li Shenggang,Sun Zhenping,Yi Xuetao and Yang Juan(Qingdao Institute for Drug Control,Qingdao 266071) |
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| Abstract: | Objective To study the effect of Qingnaozhentong Liquor on NO and NOS content in migraine models.Methods Wistar rats were randomly divided into 6 groups: high-dose,moderate-dose and low-dose group,positive control group,model control group,blank control group.Reproduce migraine model with subcutaneous injection NTG,contents of NO and NOS in serum were determined after medicine interfered 4h.Results The contents of NO and NOS of model group were heightened,which are significant compared with blank control gr... |
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| Keywords: | Qingnaozhentong Liquor migraine NO NOS |
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