注意缺陷多动障碍儿童的额叶反应抑制功能研究

目的使用近红外光学成像（fNIRS）技术研究注意缺陷多动障碍（ADHD）儿童的额叶反应抑制功能。方法采用GO-NOGO任务对19例ADHD儿童和14名健康对照进行测试,用CW5的fNIRS系统进行同步扫描。结果对照组在NOGO任务刺激时前额叶氧合血红蛋白浓度增加强于ADHD组（F=2.11,P〈0.01）;而在GO任务刺激时两组间前额叶氧合血红蛋白值变化无明显的差异（F=0.82,P=0.73）。结论 ADHD患儿的反应抑制功能不足,并且与额叶功能低下有关。

Response inhibition function of the frontal lobe in children with attention deficit and hyperactivity disorder

Objective：To investigate response inhibition function of the frontal lobe in attention deficit and hyperactivity disorder（ADHD） children by measuring signal with near-infrared spectroscopy （fNIRS）.Methods：Nineteen patients fulfilling diagnostic criteria for ADHD and 14 healthy controls were tested with GO-NOGO task.Functional data were acquired using CW5 fNIRS system.Results：Control group had a higher magnitude of oxygenation in prefrontal lobe in NOGO task （F=2.11,P0.01）.There was no significant difference between the two groups in oxyhemoglobin concentration changes in the GO task（F=0.82,P=0.73）.Conclusion：The present results suggest that children with ADHD lack response inhibition,which related to the inferior frontal lobe dysfunction.