| 以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA |
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| 引用本文： | 王德林,何士元,乔天愚. 以HPV基因通用引物行PCR检测阴茎肿瘤组织中HPV.DNA[J]. 重庆医科大学学报, 2000, 25(1): 33-34,32 |
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| 作者姓名： | 王德林 何士元 乔天愚 |
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| 作者单位： | 重庆医科大学临床学院泌尿科 400016;重庆医科大学第二临床学院泌尿科 400010 |
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| 摘 要： | 为了探讨人乳头瘤病毒感染与阴茎肿瘤的关系。用人乳头瘤病毒基因通用引物行聚合酶链反应,检测５２例阴茎鳞癌。ＨＰＶ阳性率为６７％,３１例为ＨＰＶ－１６,３例为ＨＰＶ１６／１８,１例为ＨＰＶ１１／１８。４例阴茎淋巴结转移灶标本,３例检出与原发癌一致的ＨＰＶ．ＤＮＡ。６例阴茎乳头状瘤标本,４例检出ＨＰＶ－６或１１。２０例正常阴茎包皮均阴性。提示ＨＰＶ有阴茎肿瘤的发生发展中有一定的作用,但与肿瘤的病理分级无
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| 关 键 词： | 聚合酶链反应 人乳头瘤病毒 阴茎肿瘤 |
| 文章编号： | 0253-3626(2000)01-0033-02 |
Detection of human papillomavirus (HPV) DNA in penile neoplasm by general primer mediated polymerase chain reaction |
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| WANG De-lin,et al. Detection of human papillomavirus (HPV) DNA in penile neoplasm by general primer mediated polymerase chain reaction[J]. Journal of Chongqing Medical University, 2000, 25(1): 33-34,32 |
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| Authors: | WANG De-lin et al |
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| Abstract: | The Purpose of this study was to investigate the relationship bewteen HPV infection and penile neoplasm. Using general primer mediated polymerase chain reaction(PCR) assay, The HPV. DNA was detected in 52 penile squamous cell carcinomas. The HPV.DNA positive rate was 67%.HPV-16 was identified in 31 cases, HPV16/18 in 3 and HPV11/18 in 1. HPV.DNA was also detected in 3 of 4 cases of lymph node metastasis of penile carcionoma, and they beloned to the same type of HPV as the primary carcinoma. HPV-6 or 11 was found in 4 of 6 penile papillomas. As controls, HPV had not been detected in any of 20 nonneoplastic foreskins. These data indicate that HPV is strongly associated with penile neoplasm and may play an etiologic role in the development of these neoplasms. |
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| Keywords: | Polymerase chain reation Human papillomavirus penile neoplasms. |
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