| 不同剂量伊马替尼治疗进展期胃肠间质瘤的疗效分析 |
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| 引用本文： | 刘小虎,王亚旭,龙腾,晏佳,毕德利,马东华. 不同剂量伊马替尼治疗进展期胃肠间质瘤的疗效分析[J]. 现代医药卫生, 2011, 27(15): 2248-2250 |
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| 作者姓名： | 刘小虎 王亚旭 龙腾 晏佳 毕德利 马东华 |
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| 作者单位： | 重庆医科大学附属第二医院普外科，重庆,400010 |
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| 摘 要： | 目的:探讨伊马替尼治疗进展期胃肠间质瘤(gastrointestinal stromal tumor,GIST)和外显子11及9突变病人对高剂量伊马替尼的疗效.方法:计算机检索PubMed、ISC Proceedings、ScienceDirect数据库、OVID数据库等,应用RevMan 5.0.18软件进行Meta分析.结果:共纳入5篇文献,合计2729例病人,各试验间具有基线可比性.Meta分析结果示:高剂量组800mg/d与标准剂量组400 mg/d相比,并不能明显提高患者总生存率；高剂量组800 mg/d对外显子9突变病人与外显子11突变病人相比可显著提高其总生存率(P＜0.0001).结论:对于进展期GIST病人,伊马替尼标准治疗剂量为400mg/d,但对于外显子9突变病人推荐使用高剂量伊马替尼800mg/d.
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| 关 键 词： | 胃肠道间质瘤 伊马替尼 Meta-分析 |
Efficacy analysis on different doses of imatinib for treating advanced GIST |
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| LIU Xiao-hu , WANG Ya-xu , LONG Teng , YAN Jia , BI De-li , MA Dong-hua. Efficacy analysis on different doses of imatinib for treating advanced GIST[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2011, 27(15): 2248-2250 |
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| Authors: | LIU Xiao-hu WANG Ya-xu LONG Teng YAN Jia BI De-li MA Dong-hua |
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| Affiliation: | LIU Xiao-hu,WANG Ya-xu,LONG Teng,YAN Jia,BI De-li,MA Dong-hua(Department of General Surgery,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China) |
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| Abstract: | Objective:To discuss the efficacy of two different doses of imatinib,400 mg/d and 800 mg/d,for treating advanced GIST and to investigate the curative efficacy of high dose imatinib on the mutation patients with exon 11 and exon 9.Methods:We searched the electronic databases including PubMed,ISC Proceedings,ScienceDirect and OVID.The Cochrane collaboration's RevMan 5.0.18 software was used for statistical analysis.Results:5 articles were included,total 2 729 patients.The methodological quality of the include... |
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| Keywords: | Gastrointestinal stromal tumors Imatinib mesylate Meta-analysis |
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