Characterising the KMP-11 and HSP-70 recombinant antigens' humoral immune response profile in chagasic patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Characterising the KMP-11 and HSP-70 recombinant antigens' humoral immune response profile in chagasic patients

Authors:	Ivonne D Flechas Adriana Cuellar Zulma M Cucunubá Fernando Rosas Víctor Velasco Mario Steindel del Carmen María Thomas Manuel Carlos López John Mario González Judith Concepción Puerta

Affiliation:	(1) Laboratorio de Parasitolog?a Molecular, Pontificia Universidad Javeriana, Cra. 7a No. 43-82, Ed. 50, Lab. 113, Bogot?, Colombia;(2) Grupo de Inmunobiolog?a y Biolog?a Celular, Pontificia Universidad Javeriana, Cra. 7a No. 43-82, Ed. 50, Lab. 101, Bogot?, Colombia;(3) Grupo de Parasitolog?a, Instituto Nacional de Salud, Calle 26 No. 51-60, Bogot?, Colombia;(4) Fundaci?n Cl?nica Abood Shaio, Diag, 110 No. 53-67, Bogot?, Colombia;(5) Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, 88040-900 Florian?polis, Santa Catarina, Brazil;(6) Instituto de Parasitolog?a y Biomedicina L?pez Neyra - CSIC - Parque Tecnol?gico de Ciencias de la Salud, Av del Conocimiento s/n. 18100 Armilla, Granada, Spain;(7) Grupo de Ciencias B?sicas M?dicas, Facultad de Medicina, Universidad de los Andes, Cra. 1a. No. 18A-10, Bogot?, Colombia

Abstract:	Background Antigen specificity and IgG subclass could be significant in the natural history of Chagas' disease. The relationship between the different stages of human Chagas' disease and the profiles of total IgG and its subclasses were thus analysed here; they were directed against a crude T. cruzi extract and three recombinant antigens: the T. cruzi kinetoplastid membrane protein-11 (rKMP-11), an internal fragment of the T. cruzi HSP-70 protein_192-433, and the entire Trypanosoma rangeli HSP-70 protein.

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