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基质金属蛋白酶MMP-9在口腔疣状癌中的表达及意义
引用本文:唐瞻贵,刘友良,马康黎,冯德云,姚志刚. 基质金属蛋白酶MMP-9在口腔疣状癌中的表达及意义[J]. 现代肿瘤医学, 2005, 13(1): 30-32
作者姓名:唐瞻贵  刘友良  马康黎  冯德云  姚志刚
作者单位:1. 中南大学湘雅医院口腔颌面外科,湖南,长沙,410078
2. 中南大学病理学教研室,湖南,长沙,410078
基金项目:湖南省自然科学基金项目(编号 03JJY3045)
摘    要:
目的 研究MMP-9在口腔疣状癌和鳞癌中的表达,探讨口腔疣状癌和鳞癌的不同生物行为的分子基础。方法 取 15例口腔疣状癌, 10例正常口腔粘膜, 20例口腔鳞癌(高、低分化鳞癌各 10例),应用免疫组织化学S-P法检测上述标本MMP-9表达和分布。结果 口腔疣状癌组织中MMP-9阳性表达率为 40% (6 /15),明显低于高分化鳞癌 70% (7 /10)和低分化鳞癌 80% ( 8 /10 ) (P<0. 05 );平均染色强度低于高分化鳞癌和低分化鳞癌(P<0. 05);口腔疣状癌、口腔高分化鳞癌、口腔低分化鳞癌组织中MMP-9表达均高于正常口腔粘膜组织(P<0. 05)。结论 MMP-9在口腔疣状癌的发生中起重要作用。MMP-9在口腔疣状癌、口腔高分化鳞癌、口腔低分化鳞癌的表达存在明显差异,说明口腔疣状癌是一种独立类型的恶性肿瘤。

关 键 词:口腔疣状癌 基质金属蛋白酶-9 免疫组织化学
文章编号:1672-4992(2005)01-030-03
修稿时间:2004-09-28

The expression of matrix metalloproteinase-9 in oral verrucous carcinoma
TANG Zhan-gui,LIU You-liang,MA Kang-li,et al.. The expression of matrix metalloproteinase-9 in oral verrucous carcinoma[J]. Journal of Modern Oncology, 2005, 13(1): 30-32
Authors:TANG Zhan-gui  LIU You-liang  MA Kang-li  et al.
Affiliation:TANG Zhan-gui,LIU You-liang,MA Kang-li,et al.Department of Oral and Maxillofacial Surgery,Xiangya School of Stomatology,CentralSouth University,Changsha 410078,China.
Abstract:
Objective To investigate the expression of matrix metalloproteinase-9(mmp-9) between oral verrucous carcinoma(OVC) and oral squamous cell carcinoma(OSCC) and to reveal the mechanism of the different biological characteristics between OVC and OSCC. Methods The expression of MMP-9 was examined by immunohistochemistry S-P method in 15 cases of OVC ,10 cases of well differentiated squamous cell carcinoma(WDSCC),10 cases of poorly differentiated squamous cell carcinoma(PDSCC) and 10 cases of normal oral mucosa(NM).Results The mean intensity in OVC was lower than WDSCC and PDSCC(P<0.05). MMP-9 expression in OVC was higher than NM (P<0.05).Conclusion MMP-9 expression in OVC plays an important role Different expression of MMP-9 among OVC and WDSCC,PDSCC indicats OVC is an independent entity of oral cancer.
Keywords:oral verrucous carcinoma  matrix metalloproteinase-9  immunohistochemistry
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