文拉法辛联合氯氮平治疗精神分裂症阴性症状的疗效

目的 观察文拉法辛缓释片合并氯氮平治疗精神分裂症阴性症状的疗效和不良反应.方法 采用单纯随机化法,将107例精神分裂症患者分为研究组（文拉法辛缓释片＋氯氮平）和对照组（氯氮平＋安慰剂）.于治疗前、治疗第2、4、8周末以阳性和阴性症状量表（PANSS）和阴性症状量表（SANS）评定疗效,于治疗第2、4、8周末以药物副反应量表（TESS）评定不良反应.结果 治疗4、8周末,研究组PANSS总分和阴性因子分与对照组比较,差异有统计学意义（P〈0.05）;研究组SANS总分和部分因子分与对照组比较,差异有统计学意义（P〈0.05）.治疗后第2、4、8周末,研究组TESS评分均明显低于对照组,差异有统计学意义（P〈0.05）.结论 文拉法辛缓释片治疗精神分裂症安全有效,协同氯氮平治疗精神分裂症阴性症状可增加疗效.

Venlafaxine combined with clozapine in treating negative symptoms of schizophrenia

Objective To observe the efficacy and side effects of venlafaxine combined with clozapine in the treatment of negative symptoms in schizophrenia. Methods In this random controlled study, 107 inpatients with schizophrenia were divided into two groups with one treated with venlafaxine combined clozapine and the other with clozapine combined placebo. Effects were assessed with the PANSS （Positive and Negative Syndrome Scale） and SANS （The Scale for the Assessment of Negative Symptoms） before and after 2,4,8 week treatment. Side effects were assessed with the TESS （Treatment Emergent Symptoms Scale） after 2, 4, 8 week treatment. Results The PANSS, SANS scores and negative symptom scale in venlafaxine group at weeks 4, 8 were lower than in placebo combined group （P 〈0.05）. The TESS scores at weeks 2, 4, 8 in venlafaxine group were lower than in placebo group （P 〈0. 05）. Conclusions It is suggested venlafaxine in combination with clozapine be effective and safe in treatment of the negative symptom in schizophrenia patients.