依托咪酯诱导期肌阵挛预防的研究进展

背景 依托咪酯是临床常用的静脉麻醉药之一,具有对呼吸循环影响轻微、麻醉诱导与苏醒均较快的特点,但是如何预防其诱导的肌阵挛仍然是麻醉医师所面临的挑战之一.目的 综述依托咪酯诱导期肌阵挛的预防研究进展.内容 探讨依托咪酯引起肌阵挛的机制及不同药物预先给药预防依托咪酯所致肌阵挛的效果.趋向 苯二氮革类药物、阿片类药物、肌肉松弛剂等预先给药均可对依托咪酯诱导后所致的肌阵挛产生一定的抑制作用,但最佳药物、剂量及具体机制有待进一步研究.

Research progress on the prevetion of etomidate-induced myoclonus in anesthetic induction

Background Etomidate is one of the general anesthetics used widely in clinical practice,which has little effect on both respiration and circulation and has advantage in fast induction and recovery..However,how to prevent the etomidate-induced myoclonus in anesthetsia induction is still one of the challenges that anesthetists faced.Objective To review the research progress on the prevetion of etomidate-induced myoclonus in anesthetic induction.Content This paper reviews the mechanisms of etomidate-rclated myoclonus and the effect of pretreatment of different kinds of drug on the prevention of etomidate-related myoclonus.Trend Pretreating with different drugs such as benzodiazepine,opiates and muscle relaxants,can be effective against etomidaterelated myoclonus.However,the optimal drug,dosage as well as the mechanism in myoclonus prevention are still needed further research.