| 协同刺激分子B7-H4在恶性肿瘤中的表达意义 |
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| 引用本文： | 胡文蔚,蒋敬庭,吴昌平. 协同刺激分子B7-H4在恶性肿瘤中的表达意义[J]. 医学综述, 2010, 16(1) |
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| 作者姓名： | 胡文蔚 蒋敬庭 吴昌平 |
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| 作者单位： | 苏州大学第三附属医院肿瘤生物诊疗中心,江苏,常州,213003 |
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| 基金项目： | 国家自然科学基金，常州市社会发展计划 |
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| 摘 要： | 协同刺激分子B7-H4是B7家族中的一个新成员,它能通过抑制T细胞的增殖、细胞因子的产生和细胞周期负性调控T细胞的免疫应答,同时大量表达B7-H4可以促进上皮细胞的恶性转化,保护表皮细胞免于失巢凋亡,在肿瘤的发生、进展和转归中发挥重要作用。研究B7-H4在恶性肿瘤中的表达及意义对于临床诊断具有重要作用,也为新的分子靶点治疗恶性肿瘤提供新的策略。
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| 关 键 词： | B7-H4 协同刺激信号 肿瘤,恶性 免疫逃逸 |
Expression of B7-H4 and Its Significance in Human Malignant Tumor |
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| HU Wen-wei,JIANG Jing-ting,WU Chang-ping. Expression of B7-H4 and Its Significance in Human Malignant Tumor[J]. Medical Recapitulate, 2010, 16(1) |
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| Authors: | HU Wen-wei JIANG Jing-ting WU Chang-ping |
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| Affiliation: | HU Wen-wei,JIANG Jing-ting,WU Chang-ping.(Department of Tumor Biological Treatment,the Third Affiliated Hospital of Suzhou University,Changzhou 213003,China) |
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| Abstract: | Costimulatory molecule B7-H4 is a new member of B7 family.It can negatively regulate T cells immune response by inhibiting T cell proliferation,cytokine production and cell cycle.Overexpression of B7-H4 plays an important role in initiation,progression and regression of tumor,by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis.Study of B7-H4 expression in malignant tumors is useful in clinical diagnosis and treatment,and offers new strategy to pursue for mo... |
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| Keywords: | B7-H4 |
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