| 人参皂苷Rg1对缺血性脑卒中大鼠脑组织Fas和Caspase-3蛋白表达的影响 |
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| 引用本文： | 包翠芬,刘霞,梁佳,魏嘉,秦书俭. 人参皂苷Rg1对缺血性脑卒中大鼠脑组织Fas和Caspase-3蛋白表达的影响[J]. 辽宁中医药大学学报, 2009, 0(5) |
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| 作者姓名： | 包翠芬 刘霞 梁佳 魏嘉 秦书俭 |
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| 作者单位： | 辽宁中医药大学;辽宁医学院; |
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| 摘 要： | 目的:探讨人参皂苷Rg1对缺血性脑卒中大鼠脑组织膜蛋白(Fas)、胱天蛋白酶(Caspase-3)表达的影响及其意义。方法:将大鼠随机分为假手术组、缺血性脑卒中组、人参皂苷Rg110、20、40mg/kg组、尼莫地平1mg/kg药物对照组,采用大脑中动脉闭塞法建立缺血性脑卒中模型;应用免疫组化法检测脑组织Fas、Caspase-3的表达。结果:人参皂苷Rg1各剂量组及尼莫地平组大鼠脑组织Fas、Caspase-3表达阳性细胞数明显低于缺血性脑卒中组(P<0.05)。结论:人参皂苷Rg1防治大鼠缺血性脑卒中损伤的机制可能与抑制脑组织Fas、Caspase-3表达有关,且以高剂量效果较好。
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| 关 键 词： | 人参皂苷Rg1 缺血性脑卒中 Fas Caspase-3 |
Effects of Ginsenoside Rg1 on Expressions of Fas Caspase-3 in Brain Tissue after Cerebral Arterial Thrombosis in Rats |
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| BAO Cui-fen,,LIU-Xia,LIANG-Jia,WEI-Jia,QIN Shu-jian. Effects of Ginsenoside Rg1 on Expressions of Fas Caspase-3 in Brain Tissue after Cerebral Arterial Thrombosis in Rats[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2009, 0(5) |
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| Authors: | BAO Cui-fen LIU-Xia LIANG-Jia WEI-Jia QIN Shu-jian |
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| Affiliation: | 1.Liaoning University of Traditional Chinese Medicine;Shenyang 110032;Liaoning;China;2.Liaoning Medical College;Jinzhou 121001;China |
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| Abstract: | Objective:To study the effects of Ginsenoside Rg1 on the expressions of Fas,Caspase-3 in brain tissue after cerebral arterial thrombosis in adult rats and the dosage-effect relationship. Methods:Rats were randomly divided into the sham-operative group,Model group and Ginsenoside Rg1 groups of 10 mg/kg,20 mg/kg,40mg/kg,Nimodipine group of 1 mg/kg. We adopted the middle cerebral artery occlusion(MCAO ) in rats as the cerebral arterial thrombosis model,then observed the expressions of Fas,Caspase-3 in brain ti... |
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| Keywords: | Ginsenoside Rg1 cerebral arterial thrombosis Fas Caspase-3 |
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