酮洛芬醇质体体外经皮渗透研究

目的:考察酮洛芬醇质体的体外经皮渗透特性。方法:乙醇注入法制备酮洛芬醇质体,采用Franz扩散池,以离体小鼠皮为皮肤屏障,对酮洛芬醇质体的体外经皮渗透量、稳态透皮速率进行研究,并测定24 h时皮肤中的滞留量。结果:酮洛芬醇质体体外24 h累积渗透量Q为(720.88±2.04)μg.cm-2,稳态透皮速率J为(28.15±0.20)μg.cm-2.h-1,24 h皮肤中的滞留量(50.86±1.44)μg.cm-2,与同剂量酮洛芬脂质体及其30%醇溶液相比,均有明显提高(P<0.05)。结论:醇质体可显著增加酮洛芬的体外经皮渗透,值得进一步研发。

Transdermal Penetration of Ketoprofen Ethosomes in vitro

Objective： To study the transdermal penetration of ketoprofen ethosomes in vitro.Method： The ketoprofen ethosomes were prepared by ethanol injection method.Using stripped mouse skin as the barrier,the accumulative penetration amount（Q） and the stable penetration rate（J） were investigated in Franz diffusion cells.The skin retention in 24h was studied as well.Result： In 24h,Q was（720.88±2.04）μg.cm-2,J was（28.15±0.20）μg·dermal penetration of ketoprofen in vitro,which are valuable to be studied further.