| 急性再生障碍性贫血免疫发病机制探讨 |
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| 引用本文： | 姚佳峰,徐述,许勇钢,杨晓红,李柳,刘池,刘锋,麻柔.急性再生障碍性贫血免疫发病机制探讨[J].国际输血及血液学杂志,2008,31(4). |
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| 作者姓名： | 姚佳峰 徐述 许勇钢 杨晓红 李柳 刘池 刘锋 麻柔 |
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| 作者单位： | 中国中医科学院西苑医院血液科,北京,100091 |
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| 摘 要： | 目的 探索急性再生障碍性贫血(AA)的免疫学发病机制及抗胸腺细胞球蛋白(ATG)的免疫调节机制.方法 利用流式细胞仪测定74例急性AA患者与55例正常人的T淋巴细胞亚群及其中30例接受ATG治疗前后T淋巴细胞亚群的变化.结果 与对照组相比.急性AA组的总T淋巴细胞、总B淋巴细胞、CD4+T淋巴细胞百分比均较正常组高,而CD56+、CD3+DR+百分比均较正常组低.ATG治疗有效患者(24例)治疗后CD8+、CD56+、CD3+DR+百分比增加,CD4+、CD4+/CD8+百分比下降.结论 与慢性AA的发病机制不同.急性AA CD4+T淋巴细胞百分比异常升高.推断CD4+T淋巴细胞可能主要分化为Th1细胞.起抑制造血作用.
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| 关 键 词： | 急性再生障碍性贫血 免疫机制 |
Immunological study of acute aplastic anemia |
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| YAO Jia-feng,XU Shu,XU Yong-gang,YANG Xiao-hong,LI Liu,LIU Chi,LIU Feng,MA Rou.Immunological study of acute aplastic anemia[J].International Journal of Blood Tranfusion and Hematology,2008,31(4). |
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| Authors: | YAO Jia-feng XU Shu XU Yong-gang YANG Xiao-hong LI Liu LIU Chi LIU Feng MA Rou |
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| Abstract: | Objective To explore the immunopathogenesis of acute AA and the effect of ATG in immunological regulation. Method T cell subsets of 74 acute AA patients,55 health adults and 30 acute AA patients were measured with flow eytometry after ATG therapy. Result Compared with the control, the percentage of total T, total B and CD4+ T cell count in acute AA were higher, while the percentage of CD56+,CD3+DR+ count were lower. In the 24 patients who improved after ATG therapy, the percentage of CD4+ and CD4+/CD8+ decreased, while the percentage of CDS+, CD56+ and CD3+DR + raised. Conclusion Acute AA may have a different immunity mechanism from chronic AA. CD4+T lymphocytes may be a critical factor in the pathophysiology, which would be polarized toward a Thl pattern of cytokine production to suppress haematogenesis. |
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| Keywords: | ATG |
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