卵巢恶性肿瘤VEGF mRNA和bFGF mRNA的表达及其意义

应用原位分子杂交技术研究卵巢恶性肿瘤组织中VEGFmRNA和bFGFmRNA的表达及其意义。结果发现 :浆液性腺癌和内胚窦癌两者表达阳性率高于粘液性腺癌和颗粒细胞瘤 ;临床分期Ⅰ期和未转移病例两者表达阳性率低于临床分期Ⅲ～Ⅳ期和转移病例。结果提示VEGFmRNA和bFGFmRNA表达与卵巢恶性肿瘤病理类型、临床分期和转移发生关系密切 ,阳性表达者可能预后较差。

The expression and significance of VEGF mRNA and bFGF mRNA in the malignant neoplasms of ovary

The expression and significance of VEGF mRNA and bFGF mRNA in the malignant neoplasms of ovary were studied by in situ hybridization technique. The results were that the positive rates of VEGF mRNA and bFGF mRNA were higher in the serous adenocarcinoma and embryonal carcinoma than that in the mucous adenocarcinoma and granulosa cell tumor. The positive rates of VEGF mRNA and bFGF mRNA were lower in the cases of clinical Stage Ⅰ and without metastasis than that of clinical Stage Ⅲ～Ⅳ and with metastasis. The results suggest that the expressions of VEGF mRNA and bFGF mRNA might be related to the pathological types, clinical stages, and metastasis of the malignant neoplasms of ovary and the patients who have positive expression of VEGF mRNA and bFGF mRNA might have a poor prognosis.