抗病毒口服液挥发油包合工艺研究

目的研究抗病毒口服液中含有挥发油的广藿香、石菖蒲、郁金、连翘4味药材所收集的挥发油用羟丙基-β-环糊精包合的工艺。方法采用正交试验法，以挥发油的包合率为指标确定包合物的最佳工艺，并用气相色谱（GC）法对包合前后的挥发油进行鉴别。结果包合物的最佳制备工艺为挥发油与羟丙基-β-环糊精比例1：8（mL／g），包合温度50℃，搅拌时间5h。结论经GC法鉴别，包合前后挥发油成分未改变。

Study on Inclusion Technology of Volatile Oil in Antiviral Oral Solution

Objective To optimize the inclusion process of the extracted volatile oil from four medicinal materials in Antiviral Oral Solution. Methods The inclusion condition was evaluated by orthogonal test with the inclusion rate of volatile oil as the index. Gas chromatography （GC） was used to identify the volatile oil before and after inclusion. Results The optimum preparative process for inclusion complex was established as follows： the proportion of volatile oil to hydroxypropyl （HP）- β-cyclodextrin（CD） was 1：8（mL/g）, the inclusion temperature was 50 ℃ and inclusion time was 5 h. Conclusion GC identification shows no change in the components of volatile oil before and after inclusion. The inclusion condition is reasonable and feasible.