乳腺癌化疗患者认知功能障碍发生状况及影响因素

目的探讨乳腺癌化疗患者后认知功能障碍发生状况及影响因素,为临床诊治提供依据。方法对300例乳腺癌化疗患者采用蒙特利尔认知评估量表评定认知功能,统计其临床资料,并采用单因素及多因素Logistic回归分析探讨患者认知功能障碍的影响因素。结果本组300例乳腺癌化疗患者,认知功能正常228例(76.0%),存在认知功能障碍72例(24.0%)。认知功能障碍患者年龄(≥60岁)、乳腺癌知识了解程度较差、家庭月收入(≤5000元)、运动情况(<3次·周-1)、无医疗保险、化疗时间(>3个周期)占比显著高于认知功能正常患者。Logistic回归分析显示,年龄(≥60岁)、乳腺癌知识了解程度较差、家庭月收入(≤5000元)、运动情况(<3次·周-1)、无医疗保险、化疗时间(>3个周期)是乳腺癌化疗患者发生认知功能障碍的危险因素(OR>1,P<0.05)。结论部分乳腺癌化疗患者存在认知功能障碍,其影响因素众多,应对其予以有针对性的干预,改善其认知功能。

Cognitive dysfunction and its influencing factors in breast cancer patients undergoing chemotherapy

Objective To explore the status of cognitive dysfunction and its influencing factors in breast cancer patients undergoing chemotherapy,and provide a basis for clinical diagnosis and treatment.Methods The Montreal cognitive assessment(MoCA)was used to evaluate the cognitive function of 300 breast cancer patients undergoing chemotherapy,and their clinical data were counted.Single factor and multivariate Logistic regression analysis were used to explore the influencing factors of patients'cognitive dysfunction.Results In this group of 300 breast cancer patients undergoing chemotherapy,228 cases(76.0%)had normal cognitive function and 72 cases(24.0%)had cognitive impairment.Cognitive dysfunction patients with age greater than or equal to 60 years old,poor knowledge of breast cancer,family monthly income less than or equal to 5000 yuan,exercise status less than 3 times per week,no medical insurance,chemotherapy time more than 3 cycles were significantly higher than those with normal cognitive function.Logistic regression analysis showed that age greater than or equal to 60 years old,poor knowledge of breast cancer,family monthly income less than or equal to 5,000 yuan,exercise status less than 3 times per week,no medical insurance,chemotherapy time more than 3 cycles were the risk factors of cognitive dysfunction in patients with breast cancer undergoing chemotherapy(OR>1,P<0.05).Conclusions Some breast cancer patients undergoing chemotherapy have cognitive dysfunction,which is influenced by many factors.Targeted intervention should be given to improve the degree of cognitive dysfunction.