Comparison of salivary cortisol and calculated free plasma cortisol during low-dose ACTH test in healthy subjects |
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| Authors: | Jana Kerlik Adela Penesova Miroslav Vlcek Richard Imrich Michael Vogeser Zofia Radikova |
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| Affiliation: | 1. Laboratory of Human Endocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06, Bratislava, Slovakia;2. Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia;3. Institute of Clinical Chemistry, Hospital of the University of Munich, Munich, Germany;1. Institute of Psychology, University of Kiel, Germany;2. Institute of Psychology, University of Bonn, Germany;1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia;2. Department of Neurology, Royal North Shore Hospital, University of Sydney, Australia;3. Sydney Medical School, University of Sydney, NSW, Australia |
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| Abstract: | ![]()
ObjectivesTo compare free plasma cortisol (FPC) with salivary and calculated cortisol.Design and methodsFPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women.ResultsFPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol. FPC and salivary cortisol showed the highest method agreement.ConclusionsFCIalb and salivary cortisol are preferred surrogates of FPC. |
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