Oxidative stress and myeloperoxidase activity during bacterial meningitis: Effects of febrile episodes and the BBB permeability |
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| Authors: | Dijana Miric Radoslav Katanic Bojana Kisic Lepsa Zoric Bratislav Miric Radoslav Mitic Ilija Dragojevic |
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| Affiliation: | 1. Institute of Biochemistry, Medical Faculty Pristina (Kosovska Mirtovica), Anri Dinana bb, 38220, Kosovska Mitrovica, Serbia;2. Clinic for Infectious Diseases, Medical Faculty Pristina, Kosovska Mitrovica, Serbia;3. Biomedical Research Center, Medical Faculty Pristina, Kosovska Mitrovica, Serbia;4. Department for Informatics, State University of Novi Pazar, Novi Pazar, Serbia;1. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905;2. Division of Vascular and Interventional Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905;3. Department of Clinical Statistics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905;1. Clinic for Surgery, Dentistry and Ophthalmology, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria;2. Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria;3. Institute of Population Genetics, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria;4. Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman;1. Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil;2. Department of Veterinary, Universidade Federal de Viçosa, Viçosa, MG, Brazil;1. Public Health Branch, Israel Defense Forces Medical Corps, Israel;2. Bar Ilan University, Faculty of Social Sciences, Department of Management, Israel;3. Israel Veterinary Services, Ministry of Agriculture and Rural Development, Israel;4. Clinical Virology Unit, Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel;5. Lautenberg Center for General and Tumor Immunology, The Hebrew University Faculty of Medicine, Jerusalem, Israel;6. Myers-JDC-Brookdale Institute, Jerusalem, Israel;7. Institute for Research in Military Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Israel |
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| Abstract: | ![]()
ObjectiveTo investigate participation of extracellular myeloperoxidase (MPO) in oxidative stress during different courses of the bacterial meningitis (BM).Materials and methodsWe sequentially assessed WBC count, blood-brain barrier (BBB) permeability, serum and cerebrospinal fluid (CSF) lipid peroxidation (LPO), MPO and antioxidative activity (AOA) in proven pediatric BM.ResultsBM patients exhibited increased systemic and local LPO and MPO, and reduced AOA, which was exaggerated in the febrile episodes. Serum MPO and LPO products were related to the BBB permeability at the baseline. CSF hydroperoxide level was influenced by the BBB permeability, CSF albumin concentration, and serum hydroperoxide (r = 0.502; p < 0.001, and r = 0.611; p < 0.001, and r = 0.358; p < 0.001, respectively). CSF hydroperoxide and MPO correlated in complicated cases during the study.ConclusionsThese results suggest that CSF LPO and MPO were closely related in BM, had different courses if febrile episodes had occurred, but were partly influenced by the BBB permeability. |
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