IgA Nephropathy Associated With Castleman Disease With Cutaneous Involvement |
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| Authors: | Atsushi Komatsuda Hideki Wakui Masaru Togashi Ken-Ichi Sawada |
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| Institution: | 1. Division of Rheumatology, Department of Medicine DIMED, University of Padua, Via Giustiniani 2, 35128 Padua, Italy;2. Cardiology Clinic, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy;1. Sección Reumatología, Servicio de Clínica Médica, Hospital Rivadavia, CABA, Argentina;2. Consultorios Reumatología, Clínica Bessone, Buenos Aires, Argentina;3. Servicio de Reumatología, Hospital Alemán, CABA, Argentina;4. Servicio de Reumatología, Hospital Británico, CABA, Argentina;5. Servicio de Reumatología, Hospital Córdoba, Córdoba, Argentina;6. Servicio de Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina;7. Sección Reumatología, Servicio de Clínica Médica, Hospital Tornú, CABA, Argentina;8. Servicio de Reumatología, Instituto Provincial de Rehabilitación Integral (IPRI), Santiago del Estero, Argentina;9. Centro de Reumatología, Organización Médica de Investigación (OMI), CABA, Argentina;1. Department of Neuro-Oncology, MD Anderson Cancer Center, Houston, TX 77030-4009, USA |
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| Abstract: | A 35-year-old Japanese man developed systemic lymphadenopathy during the course of immunosuppressive therapy for IgA nephropathy associated with cutaneous nodules, polyclonal hypergammaglobulinemia, and persistent increased serum C-reactive protein of unknown cause. Lymph node examination showed the plasmacytic type of Castleman disease (CD). A skin biopsy showed specific pathologic findings of CD cutaneous involvement. Considering the involvement of interleukin-6 in CD, we treated the patient with humanized anti-interleukin-6 receptor antibody. Thereafter, his symptoms and abnormal laboratory findings were improved. Cutaneous CD has rarely been described in Asian population, and renal complications in CD are uncommon and heterogeneous. To our knowledge, this is the first case of IgA nephropathy associated with multicentric CD with cutaneous involvement. |
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