| 组织定居巨噬细胞在肿瘤微环境中的作用 |
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| 引用本文： | 杨万里,任欢.组织定居巨噬细胞在肿瘤微环境中的作用[J].国际免疫学杂志,2021,44(1):86-90. |
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| 作者姓名： | 杨万里 任欢 |
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| 作者单位： | 哈尔滨医科大学免疫学教研室 150081;南方科技大学医学院，广东深圳 518055 |
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| 基金项目： | 国家自然科学基金(81871993)。 |
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| 摘 要： | 肿瘤相关巨噬细胞(tumor-associated macrophages，TAMs)是肿瘤微环境中最主要的免疫细胞群之一，在肿瘤生长、血管生成和治疗等各环节发挥重要作用。以往研究认为肿瘤微环境中TAMs主要来源于循环单核细胞，但近期研究证实，起源于胚胎卵黄囊及胎肝的组织定居巨噬细胞也可以在肿瘤微环境中分化为TAMs，...
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| 关 键 词： | 肿瘤相关巨噬细胞 单核-巨噬细胞系统 组织定居巨噬细胞 肿瘤微环境 细胞分化 |
Functional properties of tissue resident macrophages in tumor microenvironment |
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| Yang Wanli,Ren Huan.Functional properties of tissue resident macrophages in tumor microenvironment[J].International Journal of Immunology,2021,44(1):86-90. |
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| Authors: | Yang Wanli Ren Huan |
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| Institution: | (Department of Immunology,Harbin Medical University,Harbin 150081,China;School of Medicine,Southern University of Science and Technology,Shenzhen 518055,China) |
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| Abstract: | Tumor-associated macrophages(TAMs)are one of the most principal immune cell populations in tumor microenvironment which play an important role in tumor growth,angiogenesis and treatment,etc.TAMs in tumor microenvironment were considered to originate from circulating monocyte precursors exclusively.However,recent studies have demonstrated that tissue resident macrophages deriving from the embryonic yolk sac and fetal liver can also differentiate into TAMs in tumor microenvironment.It is currently believed that TAMs renews itself mainly through cell proliferation.This review summarized the origin,differentiation and role of this group of TAMs in tumor microenvironment. |
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| Keywords: | Tumor-associated macrophages Monocyte-macrophage system Tissue resident macrophages Tumor microenvironment Cell differentiation |
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